Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis.

Sage Foley; Christine Tuohy; Merran Dunford; Michael J. Grey; Heidi De Luca; Caitlin Cawley; Ana  Maldonado-Contreras; Jean Marie Houghton; Doyle V. Ward; Randy Mrsny; Beth A. McCormick

doi:10.1186/s40168-021-01137-3

Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis.

Sage Foley, Christine Tuohy, Merran Dunford, Michael J. Grey, Heidi De Luca, Caitlin Cawley, Ana Maldonado-Contreras, Jean Marie Houghton, Doyle V. Ward, Randy Mrsny, Beth A. McCormick

Research output: Contribution to journal › Article › peer-review

67 Citations (SciVal)

Abstract

P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia by mediating efflux of drugs/xenobiotics from the intestinal mucosa into the gut lumen. Recent studies bring to light that P-gp also confers a critical link in communication between intestinal mucosal barrier function and the innate immune system. Yet, despite knowledge for over 10 years that P-gp plays a central role in gastrointestinal homeostasis, the precise molecular mechanism that controls its functional expression and regulation remains unclear. Here, we assessed how the intestinal microbiome drives P-gp expression and function.

Original language	English
Article number	183 (2021)
Journal	Microbiome
Volume	9
Early online date	7 Sept 2021
DOIs	https://doi.org/10.1186/s40168-021-01137-3
Publication status	Published - 7 Sept 2021

Keywords

IBD
Microbiome
Inflammation
P-glycoprotein
Endocannabinoid
Metabolites
Inflammatory bowel diseases
Ulcerative Colitis
Multi-drug resistance transporter
Intestinal epithelium
Short-chain fatty acids
Secondary bile acids

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10.1186/s40168-021-01137-3Licence: CC BY

Avance 300 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)
Material and Chemical Characterisation (MC2)
Facility/equipment: Equipment
UHPLC Maxis QTOF MS coupled to an ultra high-pressure Liquid Chromatography system
Material and Chemical Characterisation (MC2)
Facility/equipment: Equipment

Cite this

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title = "Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis.",

abstract = "P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia by mediating efflux of drugs/xenobiotics from the intestinal mucosa into the gut lumen. Recent studies bring to light that P-gp also confers a critical link in communication between intestinal mucosal barrier function and the innate immune system. Yet, despite knowledge for over 10 years that P-gp plays a central role in gastrointestinal homeostasis, the precise molecular mechanism that controls its functional expression and regulation remains unclear. Here, we assessed how the intestinal microbiome drives P-gp expression and function.",

keywords = "IBD, Microbiome, Inflammation, P-glycoprotein, Endocannabinoid, Metabolites, Inflammatory bowel diseases, Ulcerative Colitis, Multi-drug resistance transporter, Intestinal epithelium, Short-chain fatty acids, Secondary bile acids",

author = "Sage Foley and Christine Tuohy and Merran Dunford and Grey, {Michael J.} and {De Luca}, Heidi and Caitlin Cawley and Ana Maldonado-Contreras and Houghton, {Jean Marie} and Ward, {Doyle V.} and Randy Mrsny and McCormick, {Beth A.}",

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day = "7",

doi = "10.1186/s40168-021-01137-3",

language = "English",

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journal = "Microbiome",

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publisher = "BioMed Central",

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TY - JOUR

T1 - Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis.

AU - Foley, Sage

AU - Tuohy, Christine

AU - Dunford, Merran

AU - Grey, Michael J.

AU - De Luca, Heidi

AU - Cawley, Caitlin

AU - Maldonado-Contreras, Ana

AU - Houghton, Jean Marie

AU - Ward, Doyle V.

AU - Mrsny, Randy

AU - McCormick, Beth A.

PY - 2021/9/7

Y1 - 2021/9/7

N2 - P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia by mediating efflux of drugs/xenobiotics from the intestinal mucosa into the gut lumen. Recent studies bring to light that P-gp also confers a critical link in communication between intestinal mucosal barrier function and the innate immune system. Yet, despite knowledge for over 10 years that P-gp plays a central role in gastrointestinal homeostasis, the precise molecular mechanism that controls its functional expression and regulation remains unclear. Here, we assessed how the intestinal microbiome drives P-gp expression and function.

AB - P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia by mediating efflux of drugs/xenobiotics from the intestinal mucosa into the gut lumen. Recent studies bring to light that P-gp also confers a critical link in communication between intestinal mucosal barrier function and the innate immune system. Yet, despite knowledge for over 10 years that P-gp plays a central role in gastrointestinal homeostasis, the precise molecular mechanism that controls its functional expression and regulation remains unclear. Here, we assessed how the intestinal microbiome drives P-gp expression and function.

KW - IBD

KW - Microbiome

KW - Inflammation

KW - P-glycoprotein

KW - Endocannabinoid

KW - Metabolites

KW - Inflammatory bowel diseases

KW - Ulcerative Colitis

KW - Multi-drug resistance transporter

KW - Intestinal epithelium

KW - Short-chain fatty acids

KW - Secondary bile acids

U2 - 10.1186/s40168-021-01137-3

DO - 10.1186/s40168-021-01137-3

M3 - Article

SN - 2049-2618

VL - 9

JO - Microbiome

JF - Microbiome

M1 - 183 (2021)

ER -

Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis.

Abstract

Keywords

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Equipment

Avance 300 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

UHPLC Maxis QTOF MS coupled to an ultra high-pressure Liquid Chromatography system

Cite this