Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis.

Sage Foley; Christine Tuohy; Merran Dunford; Michael J. Grey; Heidi De Luca; Caitlin Cawley; Ana  Maldonado-Contreras; Jean Marie Houghton; Doyle V. Ward; Randy Mrsny; Beth A. McCormick

doi:10.1186/s40168-021-01137-3

Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis.

Sage Foley, Christine Tuohy, Merran Dunford, Michael J. Grey, Heidi De Luca, Caitlin Cawley, Ana Maldonado-Contreras, Jean Marie Houghton, Doyle V. Ward, Randy Mrsny, Beth A. McCormick

Research output: Contribution to journal › Article › peer-review

Abstract

P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia by mediating efflux of drugs/xenobiotics from the intestinal mucosa into the gut lumen. Recent studies bring to light that P-gp also confers a critical link in communication between intestinal mucosal barrier function and the innate immune system. Yet, despite knowledge for over 10 years that P-gp plays a central role in gastrointestinal homeostasis, the precise molecular mechanism that controls its functional expression and regulation remains unclear. Here, we assessed how the intestinal microbiome drives P-gp expression and function.

Original language	English
Article number	183 (2021)
Journal	Microbiome
Volume	9
Early online date	7 Sep 2021
DOIs	https://doi.org/10.1186/s40168-021-01137-3
Publication status	Published - 7 Sep 2021

Keywords

IBD
Microbiome
Inflammation
P-glycoprotein
Endocannabinoid
Metabolites
Inflammatory bowel diseases
Ulcerative Colitis
Multi-drug resistance transporter
Intestinal epithelium
Short-chain fatty acids
Secondary bile acids

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10.1186/s40168-021-01137-3Licence: CC BY

Cite this

Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis. / Foley, Sage; Tuohy, Christine; Dunford, Merran; Grey, Michael J.; De Luca, Heidi; Cawley, Caitlin; Maldonado-Contreras, Ana; Houghton, Jean Marie; Ward, Doyle V.; Mrsny, Randy; McCormick, Beth A.

In: Microbiome, Vol. 9, 183 (2021), 07.09.2021.

Research output: Contribution to journal › Article › peer-review

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AU - De Luca, Heidi

AU - Cawley, Caitlin

AU - Maldonado-Contreras, Ana

AU - Houghton, Jean Marie

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AU - McCormick, Beth A.

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KW - Microbiome

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KW - Endocannabinoid

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KW - Inflammatory bowel diseases

KW - Ulcerative Colitis

KW - Multi-drug resistance transporter

KW - Intestinal epithelium

KW - Short-chain fatty acids

KW - Secondary bile acids

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