Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis.

Sage Foley, Christine Tuohy, Merran Dunford, Michael J. Grey, Heidi De Luca, Caitlin Cawley, Ana Maldonado-Contreras, Jean Marie Houghton, Doyle V. Ward, Randy Mrsny, Beth A. McCormick

Research output: Contribution to journalArticlepeer-review

Abstract

P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia by mediating efflux of drugs/xenobiotics from the intestinal mucosa into the gut lumen. Recent studies bring to light that P-gp also confers a critical link in communication between intestinal mucosal barrier function and the innate immune system. Yet, despite knowledge for over 10 years that P-gp plays a central role in gastrointestinal homeostasis, the precise molecular mechanism that controls its functional expression and regulation remains unclear. Here, we assessed how the intestinal microbiome drives P-gp expression and function.
Original languageEnglish
Article number183 (2021)
JournalMicrobiome
Volume9
Early online date7 Sep 2021
DOIs
Publication statusPublished - 7 Sep 2021

Keywords

  • IBD
  • Microbiome
  • Inflammation
  • P-glycoprotein
  • Endocannabinoid
  • Metabolites
  • Inflammatory bowel diseases
  • Ulcerative Colitis
  • Multi-drug resistance transporter
  • Intestinal epithelium
  • Short-chain fatty acids
  • Secondary bile acids

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