GRAPPA-OMERACT consensus-based recommendations and research agenda for use of composite measures and treatment targets in PsA

Laura C Coates; Oliver Fitzgerald; Joseph F Merola; Josef Smolen; Leonieke J J van Mens; Heidi Bertheussen; Wolf-Henning Boehncke; Kristina Callis Duffin; Willemina Campbell; Maarten de Wit; Dafna D Gladman; Alice Gottlieb; Jana James; Arthur F Kavanaugh; Lars Erik Kristensen; Tore K Kvien; Thomas Luger; Neil McHugh; Philip J Mease; Peter Nash; Alexis Ogdie; Cheryl F Rosen; Vibeke Strand; William Tillett; Douglas J Veale; Philip S Helliwell

doi:10.1002/art.40391

GRAPPA-OMERACT consensus-based recommendations and research agenda for use of composite measures and treatment targets in PsA

Laura C Coates, Oliver Fitzgerald, Joseph F Merola, Josef Smolen, Leonieke J J van Mens, Heidi Bertheussen, Wolf-Henning Boehncke, Kristina Callis Duffin, Willemina Campbell, Maarten de Wit, Dafna D Gladman, Alice Gottlieb, Jana James, Arthur F Kavanaugh, Lars Erik Kristensen, Tore K Kvien, Thomas Luger, Neil McHugh, Philip J Mease, Peter NashAlexis Ogdie, Cheryl F Rosen, Vibeke Strand, William Tillett, Douglas J Veale, Philip S Helliwell

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Abstract

BACKGROUND: Many composite disease activity measures and targets have been developed for psoriatic arthritis (PsA). This GRAPPA-OMERACT work stream aimed to further the development of consensus among physicians and patients.

METHODS: Prior to the meeting, physicians and patients were surveyed on outcome measures. A consensus meeting (26 rheumatologists, dermatologists, and patient representatives) reviewed evidence on composite measures and potential treatment targets, plus survey results. After discussions, participants voted on proposals for use and consensus was established in a second survey.

RESULTS: Survey results from 128 HCPS and 139 patients were analysed alongside a SLR summarising evidence. A weighted vote was cast for composite measures (for RCTs, most popular measures were PASDAS [40 votes] and GRACE [28 votes]; for clinical practice, most popular were 3-VAS [45 votes], DAPSA [26 votes]). After discussion there was no consensus on a composite measure. The group agreed that several composite measures could be used. Future studies should allow further validation and comparison. The group unanimously agreed that remission should be the ideal target with minimal/low disease activity a feasible alternative. The target should include assessment of musculoskeletal disease, skin and health related quality of life. The group recommended a target of treatment as VLDA, or MDA.

CONCLUSIONS: Consensus was not reached on a continuous measure of disease activity. In the interim the group recommends several composites. Consensus was reached on a treatment target of VLDA/MDA. An extensive research agenda was composed and recommends that data on all PsA clinical domains be collected in ongoing studies. This article is protected by copyright. All rights reserved.

Original language	English
Pages (from-to)	345-355
Journal	Arthritis & Rheumatology
Volume	70
Issue number	3
Early online date	28 Nov 2017
DOIs	https://doi.org/10.1002/art.40391
Publication status	Published - 31 Mar 2018

Keywords

Journal Article

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10.1002/art.40391

GRAPPA-OMERACT consensus-based recommendations
This is the peer reviewed version of the following article: Coates, LC, Fitzgerald, O, Merola, JF, Smolen, J, van Mens, LJJ, Bertheussen, H, Boehncke, W-H, Callis Duffin, K, Campbell, W, de Wit, M, Gladman, DD, Gottlieb, A, James, J, Kavanaugh, AF, Kristensen, LE, Kvien, TK, Luger, T, McHugh, N, Mease, PJ, Nash, P, Ogdie, A, Rosen, CF, Strand, V, Tillett, W, Veale, DJ & Helliwell, PS 2017, 'GRAPPA-OMERACT consensus-based recommendations and research agenda for use of composite measures and treatment targets in PsA' Arthritis & Rheumatology, which has been published in final form at https://doi.org/10.1002/art.40391. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 259 KB

Outcome Measures for Randomised Controlled Trials in Psoriatic Arthritis
Tillett, W. (PI)
1/09/16 → 3/07/20
Project: Central government, health and local authorities

Cite this

Coates, L. C., Fitzgerald, O., Merola, J. F., Smolen, J., van Mens, L. J. J., Bertheussen, H., Boehncke, W.-H., Callis Duffin, K., Campbell, W., de Wit, M., Gladman, D. D., Gottlieb, A., James, J., Kavanaugh, A. F., Kristensen, L. E., Kvien, T. K., Luger, T., McHugh, N., Mease, P. J., ... Helliwell, P. S. (2018). GRAPPA-OMERACT consensus-based recommendations and research agenda for use of composite measures and treatment targets in PsA. Arthritis & Rheumatology, 70(3), 345-355. https://doi.org/10.1002/art.40391

Coates, LC, Fitzgerald, O, Merola, JF, Smolen, J, van Mens, LJJ, Bertheussen, H, Boehncke, W-H, Callis Duffin, K, Campbell, W, de Wit, M, Gladman, DD, Gottlieb, A, James, J, Kavanaugh, AF, Kristensen, LE, Kvien, TK, Luger, T, McHugh, N, Mease, PJ, Nash, P, Ogdie, A, Rosen, CF, Strand, V, Tillett, W, Veale, DJ & Helliwell, PS 2018, 'GRAPPA-OMERACT consensus-based recommendations and research agenda for use of composite measures and treatment targets in PsA', Arthritis & Rheumatology, vol. 70, no. 3, pp. 345-355. https://doi.org/10.1002/art.40391

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T1 - GRAPPA-OMERACT consensus-based recommendations and research agenda for use of composite measures and treatment targets in PsA

AU - Coates, Laura C

AU - Fitzgerald, Oliver

AU - Merola, Joseph F

AU - Smolen, Josef

AU - van Mens, Leonieke J J

AU - Bertheussen, Heidi

AU - Boehncke, Wolf-Henning

AU - Callis Duffin, Kristina

AU - Campbell, Willemina

AU - de Wit, Maarten

AU - Gladman, Dafna D

AU - Gottlieb, Alice

AU - James, Jana

AU - Kavanaugh, Arthur F

AU - Kristensen, Lars Erik

AU - Kvien, Tore K

AU - Luger, Thomas

AU - McHugh, Neil

AU - Mease, Philip J

AU - Nash, Peter

AU - Ogdie, Alexis

AU - Rosen, Cheryl F

AU - Strand, Vibeke

AU - Tillett, William

AU - Veale, Douglas J

AU - Helliwell, Philip S

PY - 2018/3/31

Y1 - 2018/3/31

N2 - BACKGROUND: Many composite disease activity measures and targets have been developed for psoriatic arthritis (PsA). This GRAPPA-OMERACT work stream aimed to further the development of consensus among physicians and patients.METHODS: Prior to the meeting, physicians and patients were surveyed on outcome measures. A consensus meeting (26 rheumatologists, dermatologists, and patient representatives) reviewed evidence on composite measures and potential treatment targets, plus survey results. After discussions, participants voted on proposals for use and consensus was established in a second survey.RESULTS: Survey results from 128 HCPS and 139 patients were analysed alongside a SLR summarising evidence. A weighted vote was cast for composite measures (for RCTs, most popular measures were PASDAS [40 votes] and GRACE [28 votes]; for clinical practice, most popular were 3-VAS [45 votes], DAPSA [26 votes]). After discussion there was no consensus on a composite measure. The group agreed that several composite measures could be used. Future studies should allow further validation and comparison. The group unanimously agreed that remission should be the ideal target with minimal/low disease activity a feasible alternative. The target should include assessment of musculoskeletal disease, skin and health related quality of life. The group recommended a target of treatment as VLDA, or MDA.CONCLUSIONS: Consensus was not reached on a continuous measure of disease activity. In the interim the group recommends several composites. Consensus was reached on a treatment target of VLDA/MDA. An extensive research agenda was composed and recommends that data on all PsA clinical domains be collected in ongoing studies. This article is protected by copyright. All rights reserved.

AB - BACKGROUND: Many composite disease activity measures and targets have been developed for psoriatic arthritis (PsA). This GRAPPA-OMERACT work stream aimed to further the development of consensus among physicians and patients.METHODS: Prior to the meeting, physicians and patients were surveyed on outcome measures. A consensus meeting (26 rheumatologists, dermatologists, and patient representatives) reviewed evidence on composite measures and potential treatment targets, plus survey results. After discussions, participants voted on proposals for use and consensus was established in a second survey.RESULTS: Survey results from 128 HCPS and 139 patients were analysed alongside a SLR summarising evidence. A weighted vote was cast for composite measures (for RCTs, most popular measures were PASDAS [40 votes] and GRACE [28 votes]; for clinical practice, most popular were 3-VAS [45 votes], DAPSA [26 votes]). After discussion there was no consensus on a composite measure. The group agreed that several composite measures could be used. Future studies should allow further validation and comparison. The group unanimously agreed that remission should be the ideal target with minimal/low disease activity a feasible alternative. The target should include assessment of musculoskeletal disease, skin and health related quality of life. The group recommended a target of treatment as VLDA, or MDA.CONCLUSIONS: Consensus was not reached on a continuous measure of disease activity. In the interim the group recommends several composites. Consensus was reached on a treatment target of VLDA/MDA. An extensive research agenda was composed and recommends that data on all PsA clinical domains be collected in ongoing studies. This article is protected by copyright. All rights reserved.

KW - Journal Article

U2 - 10.1002/art.40391

DO - 10.1002/art.40391

M3 - Article

C2 - 29193765

SN - 2326-5191

VL - 70

SP - 345

EP - 355

JO - Arthritis & Rheumatology

JF - Arthritis & Rheumatology

IS - 3

ER -

GRAPPA-OMERACT consensus-based recommendations and research agenda for use of composite measures and treatment targets in PsA

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Outcome Measures for Randomised Controlled Trials in Psoriatic Arthritis

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