Graphene Oxide Composite Fibres for Therapeutic Fabrics

Hannah Leese, Maveendra Durailingam, Theo Roffe, Ria Atri

Research output: Contribution to journalArticlepeer-review

Abstract

Topical administration of various therapeutic factors at different stages of healing has the potential to enhance wound healing rates and reduce pain of chronic wounds. Here, the potential of utilising therapeutic fibres as wound dressings and/or sutures, is demonstrated by wet-spinning graphene oxide (GO) and aspirin adsorbed GO with polyvinyl alcohol, into drug eluting composite fibres. By varying the load of GO in the composite fibres it was possible to tailor strength, stiffness and stretchability. GO loadings of 5 wt.% resulted in fibres five times stronger than polyvinyl alcohol alone. Low loadings of GO 0.2–0.4 wt.% produced super-stretchable fibres. The drug loaded composite fibres exhibited a slow release of aspirin over a period of 3 d which is attributed to the π–π interactions between the GO and aspirin. These composite fibres demonstrate promise for incorporating other biological factors using GO as a vector, as well as creating textiles that can deliver therapeutics in a sustained manner, leading to flexible wearable therapeutics and sutures in the future.
Original languageEnglish
Article number044010
JournalJournal of Physics: Materials
Volume4
Issue number4
Early online date6 Jul 2021
DOIs
Publication statusPublished - 2 Aug 2021

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