@article{8446d564ab2943c392bf834f4bfb7d70,
title = "Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy",
abstract = "Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and αvβ3 integrin receptors) targeting function, denoted as GNR-Man/PRGD, for targeted photothermal treatment (PTT) of TNBC. The GNR-Man/PRGD ensembles were constructed through the solution-based self-assembly of mannose-grafted GNRs (GNR-Man) with a pyrene-tagged αvβ3 integrin ligand (PRGD). Enhanced PTT efficacies were achieved both in vitro and in vivo compared to that of the non-targeting equivalents. Tumor-bearing live mice were administered (tail vein) with GNR-Man/PRGD and then each mice group was subjected to PTT. Remarkably, GNR-Man/PRGD induced complete ablation of the solid tumors, and no tumor regrowth was observed over a period of 15 days. This study demonstrates a new and promising platform for the development of photothermal nanomaterials for targeted tumor therapy. This journal is",
author = "Dou, {Wei Tao} and Fugui Xu and Xu, {Chen Xi} and Jie Gao and Ru, {Hong Bo} and Xiangfeng Luan and Jiacheng Zhang and Ling Zhu and Sedgwick, {Adam C.} and Chen, {Guo Rong} and Yi Zang and James, {Tony D.} and He Tian and Jia Li and Yiyong Mai and He, {Xiao Peng}",
note = "Funding Information: The authors thank the National Natural Science Foundation of China (No. 21788102, 91853201, 21774076 and 21776078), The National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100), the Program of Shanghai Academic Research Leader (19XD1421700), the Fundamental Research Funds for the Central Universities (222201717003), National Postdoctoral Program for Innovative Talents (BX20190115), Shanghai Post-doctoral Excellence Program (2019044) and China Postdoctoral Science Foundation (2020M681206) for nancial support. The Instrumental Analysis Center of Shanghai Jiao Tong University is also acknowledged for some measurements. TDJ wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). ",
year = "2021",
month = sep,
day = "7",
doi = "10.1039/d1sc02154k",
language = "English",
volume = "12",
pages = "11089--11097",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "33",
}
