Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy

Wei Tao Dou, Fugui Xu, Chen Xi Xu, Jie Gao, Hong Bo Ru, Xiangfeng Luan, Jiacheng Zhang, Ling Zhu, Adam C. Sedgwick, Guo Rong Chen, Yi Zang, Tony D. James, He Tian, Jia Li, Yiyong Mai, Xiao Peng He

Research output: Contribution to journalArticlepeer-review

Abstract

Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and αvβ3 integrin receptors) targeting function, denoted as GNR-Man/PRGD, for targeted photothermal treatment (PTT) of TNBC. The GNR-Man/PRGD ensembles were constructed through the solution-based self-assembly of mannose-grafted GNRs (GNR-Man) with a pyrene-tagged αvβ3 integrin ligand (PRGD). Enhanced PTT efficacies were achieved both in vitro and in vivo compared to that of the non-targeting equivalents. Tumor-bearing live mice were administered (tail vein) with GNR-Man/PRGD and then each mice group was subjected to PTT. Remarkably, GNR-Man/PRGD induced complete ablation of the solid tumors, and no tumor regrowth was observed over a period of 15 days. This study demonstrates a new and promising platform for the development of photothermal nanomaterials for targeted tumor therapy. This journal is

Original languageEnglish
Pages (from-to)11089-11097
Number of pages9
JournalChemical Science
Volume12
Issue number33
Early online date20 Jul 2021
DOIs
Publication statusPublished - 7 Sep 2021

ASJC Scopus subject areas

  • Chemistry(all)

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