Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy

Wei Tao Dou; Fugui Xu; Chen Xi Xu; Jie Gao; Hong Bo Ru; Xiangfeng Luan; Jiacheng Zhang; Ling Zhu; Adam C. Sedgwick; Guo Rong Chen; Yi Zang; Tony D. James; He Tian; Jia Li; Yiyong Mai; Xiao Peng He

doi:10.1039/d1sc02154k

Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy

Wei Tao Dou, Fugui Xu, Chen Xi Xu, Jie Gao, Hong Bo Ru, Xiangfeng Luan, Jiacheng Zhang, Ling Zhu, Adam C. Sedgwick, Guo Rong Chen, Yi Zang, Tony D. James, He Tian, Jia Li, Yiyong Mai, Xiao Peng He

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

17 Citations (SciVal)

Abstract

Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and αvβ3 integrin receptors) targeting function, denoted as GNR-Man/PRGD, for targeted photothermal treatment (PTT) of TNBC. The GNR-Man/PRGD ensembles were constructed through the solution-based self-assembly of mannose-grafted GNRs (GNR-Man) with a pyrene-tagged αvβ3 integrin ligand (PRGD). Enhanced PTT efficacies were achieved both in vitro and in vivo compared to that of the non-targeting equivalents. Tumor-bearing live mice were administered (tail vein) with GNR-Man/PRGD and then each mice group was subjected to PTT. Remarkably, GNR-Man/PRGD induced complete ablation of the solid tumors, and no tumor regrowth was observed over a period of 15 days. This study demonstrates a new and promising platform for the development of photothermal nanomaterials for targeted tumor therapy. This journal is

Original language	English
Pages (from-to)	11089-11097
Number of pages	9
Journal	Chemical Science
Volume	12
Issue number	33
Early online date	20 Jul 2021
DOIs	https://doi.org/10.1039/d1sc02154k
Publication status	Published - 7 Sept 2021

Bibliographical note

Funding Information:
The authors thank the National Natural Science Foundation of China (No. 21788102, 91853201, 21774076 and 21776078), The National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100), the Program of Shanghai Academic Research Leader (19XD1421700), the Fundamental Research Funds for the Central Universities (222201717003), National Postdoctoral Program for Innovative Talents (BX20190115), Shanghai Post-doctoral Excellence Program (2019044) and China Postdoctoral Science Foundation (2020M681206) for nancial support. The Instrumental Analysis Center of Shanghai Jiao Tong University is also acknowledged for some measurements. TDJ wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

Funding

The authors thank the National Natural Science Foundation of China (No. 21788102, 91853201, 21774076 and 21776078), The National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100), the Program of Shanghai Academic Research Leader (19XD1421700), the Fundamental Research Funds for the Central Universities (222201717003), National Postdoctoral Program for Innovative Talents (BX20190115), Shanghai Post-doctoral Excellence Program (2019044) and China Postdoctoral Science Foundation (2020M681206) for nancial support. The Instrumental Analysis Center of Shanghai Jiao Tong University is also acknowledged for some measurements. TDJ wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

ASJC Scopus subject areas

General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/d1sc02154kLicence: CC BY

Cite this

Dou, W. T., Xu, F., Xu, C. X., Gao, J., Ru, H. B., Luan, X., Zhang, J., Zhu, L., Sedgwick, A. C., Chen, G. R., Zang, Y., James, T. D., Tian, H., Li, J., Mai, Y., & He, X. P. (2021). Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy. Chemical Science, 12(33), 11089-11097. https://doi.org/10.1039/d1sc02154k

@article{8446d564ab2943c392bf834f4bfb7d70,

title = "Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy",

abstract = "Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and αvβ3 integrin receptors) targeting function, denoted as GNR-Man/PRGD, for targeted photothermal treatment (PTT) of TNBC. The GNR-Man/PRGD ensembles were constructed through the solution-based self-assembly of mannose-grafted GNRs (GNR-Man) with a pyrene-tagged αvβ3 integrin ligand (PRGD). Enhanced PTT efficacies were achieved both in vitro and in vivo compared to that of the non-targeting equivalents. Tumor-bearing live mice were administered (tail vein) with GNR-Man/PRGD and then each mice group was subjected to PTT. Remarkably, GNR-Man/PRGD induced complete ablation of the solid tumors, and no tumor regrowth was observed over a period of 15 days. This study demonstrates a new and promising platform for the development of photothermal nanomaterials for targeted tumor therapy. This journal is",

author = "Dou, {Wei Tao} and Fugui Xu and Xu, {Chen Xi} and Jie Gao and Ru, {Hong Bo} and Xiangfeng Luan and Jiacheng Zhang and Ling Zhu and Sedgwick, {Adam C.} and Chen, {Guo Rong} and Yi Zang and James, {Tony D.} and He Tian and Jia Li and Yiyong Mai and He, {Xiao Peng}",

note = "Funding Information: The authors thank the National Natural Science Foundation of China (No. 21788102, 91853201, 21774076 and 21776078), The National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100), the Program of Shanghai Academic Research Leader (19XD1421700), the Fundamental Research Funds for the Central Universities (222201717003), National Postdoctoral Program for Innovative Talents (BX20190115), Shanghai Post-doctoral Excellence Program (2019044) and China Postdoctoral Science Foundation (2020M681206) for nancial support. The Instrumental Analysis Center of Shanghai Jiao Tong University is also acknowledged for some measurements. TDJ wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). ",

year = "2021",

month = sep,

day = "7",

doi = "10.1039/d1sc02154k",

language = "English",

volume = "12",

pages = "11089--11097",

journal = "Chemical Science",

issn = "2041-6520",

publisher = "Royal Society of Chemistry",

number = "33",

}

TY - JOUR

T1 - Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy

AU - Dou, Wei Tao

AU - Xu, Fugui

AU - Xu, Chen Xi

AU - Gao, Jie

AU - Ru, Hong Bo

AU - Luan, Xiangfeng

AU - Zhang, Jiacheng

AU - Zhu, Ling

AU - Sedgwick, Adam C.

AU - Chen, Guo Rong

AU - Zang, Yi

AU - James, Tony D.

AU - Tian, He

AU - Li, Jia

AU - Mai, Yiyong

AU - He, Xiao Peng

N1 - Funding Information: The authors thank the National Natural Science Foundation of China (No. 21788102, 91853201, 21774076 and 21776078), The National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100), the Program of Shanghai Academic Research Leader (19XD1421700), the Fundamental Research Funds for the Central Universities (222201717003), National Postdoctoral Program for Innovative Talents (BX20190115), Shanghai Post-doctoral Excellence Program (2019044) and China Postdoctoral Science Foundation (2020M681206) for nancial support. The Instrumental Analysis Center of Shanghai Jiao Tong University is also acknowledged for some measurements. TDJ wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

PY - 2021/9/7

Y1 - 2021/9/7

N2 - Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and αvβ3 integrin receptors) targeting function, denoted as GNR-Man/PRGD, for targeted photothermal treatment (PTT) of TNBC. The GNR-Man/PRGD ensembles were constructed through the solution-based self-assembly of mannose-grafted GNRs (GNR-Man) with a pyrene-tagged αvβ3 integrin ligand (PRGD). Enhanced PTT efficacies were achieved both in vitro and in vivo compared to that of the non-targeting equivalents. Tumor-bearing live mice were administered (tail vein) with GNR-Man/PRGD and then each mice group was subjected to PTT. Remarkably, GNR-Man/PRGD induced complete ablation of the solid tumors, and no tumor regrowth was observed over a period of 15 days. This study demonstrates a new and promising platform for the development of photothermal nanomaterials for targeted tumor therapy. This journal is

AB - Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and αvβ3 integrin receptors) targeting function, denoted as GNR-Man/PRGD, for targeted photothermal treatment (PTT) of TNBC. The GNR-Man/PRGD ensembles were constructed through the solution-based self-assembly of mannose-grafted GNRs (GNR-Man) with a pyrene-tagged αvβ3 integrin ligand (PRGD). Enhanced PTT efficacies were achieved both in vitro and in vivo compared to that of the non-targeting equivalents. Tumor-bearing live mice were administered (tail vein) with GNR-Man/PRGD and then each mice group was subjected to PTT. Remarkably, GNR-Man/PRGD induced complete ablation of the solid tumors, and no tumor regrowth was observed over a period of 15 days. This study demonstrates a new and promising platform for the development of photothermal nanomaterials for targeted tumor therapy. This journal is

UR - http://www.scopus.com/inward/record.url?scp=85113733679&partnerID=8YFLogxK

U2 - 10.1039/d1sc02154k

DO - 10.1039/d1sc02154k

M3 - Article

AN - SCOPUS:85113733679

SN - 2041-6520

VL - 12

SP - 11089

EP - 11097

JO - Chemical Science

JF - Chemical Science

IS - 33

ER -

Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this