The improved synthesis of gamma-, delta- and epsilon-lactones using a dinuclear N-heterocyclic carbene (NHC)-gold(I) catalyst is reported. This solvent-free process provides access to gamma- and delta-lactones in high regio- and stereoselectivity. Reactions were performed at low catalyst loadings and without the need for any additives. The use of a digold pre-catalyst provides a new synthetic route to functionalised epsilon-lactones, poorly accessible using previous methodologies.
- gold catalysis
- low catalyst loading
Gasperini, D., Maggi, L., Dupuy, S., Veenboer, R. M. P., Cordes, D., Slawin, A. M. Z., & Nolan, S. P. (2016). Gold(I)-Catalysed Cyclisation of Alkynoic Acids: Towards an Efficient and Eco-Friendly Synthesis of gamma-, delta- and epsilon-Lactones. Advanced Synthesis & Catalysis, 358, 3857-3862. https://doi.org/10.1002/adsc.201600575