Gold(I)-Catalysed Cyclisation of Alkynoic Acids: Towards an Efficient and Eco-Friendly Synthesis of gamma-, delta- and epsilon-Lactones

Danila Gasperini, Lorenzo Maggi, Stéphanie Dupuy, Richard M. P. Veenboer, David Cordes, Alexandra M.z. Slawin, Steven P. Nolan

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The improved synthesis of gamma-, delta- and epsilon-lactones using a dinuclear N-heterocyclic carbene (NHC)-gold(I) catalyst is reported. This solvent-free process provides access to gamma- and delta-lactones in high regio- and stereoselectivity. Reactions were performed at low catalyst loadings and without the need for any additives. The use of a digold pre-catalyst provides a new synthetic route to functionalised epsilon-lactones, poorly accessible using previous methodologies.
Original languageEnglish
Pages (from-to)3857-3862
Number of pages6
JournalAdvanced Synthesis & Catalysis
Early online date23 Nov 2016
Publication statusPublished - 7 Dec 2016


  • gold catalysis
  • lactones
  • low catalyst loading
  • NHC
  • solven-free

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