The Au(I)-catalysed rearrangement of propargylic esters formed from an ynamide has been studied. The reaction is facile, and when conducted in the presence of a reactive indole nucleophile, leads to a cascade process whereby γ-indolyl α-acyloxyenamides are formed in good yield and excellent E-stereoselectivity.
Heffernan, S. J., Beddoes, J. M., Mahon, M. F., Hennessy, A. J., & Carbery, D. R. (2013). Gold-catalysed cascade rearrangements of ynamide propargyl esters. Chemical Communications, 49(23), 2314-2316. https://doi.org/10.1039/c3cc00273j