Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

Lei Dong; Yi Zang; Dan Zhou; Xiao Peng He; Guo Rong Chen; Tony D. James; Jia Li

doi:10.1039/c5cc04357c

Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

Lei Dong, Yi Zang, Dan Zhou, Xiao Peng He, Guo Rong Chen, Tony D. James, Jia Li

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61 Citations (SciVal)

Abstract

With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.

Original language	English
Pages (from-to)	11852-11855
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	59
Early online date	18 Jun 2015
DOIs	https://doi.org/10.1039/c5cc04357c
Publication status	Published - 28 Jul 2015

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title = "Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe",

abstract = "With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.",

author = "Lei Dong and Yi Zang and Dan Zhou and He, {Xiao Peng} and Chen, {Guo Rong} and James, {Tony D.} and Jia Li",

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T1 - Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

AU - Dong, Lei

AU - Zang, Yi

AU - Zhou, Dan

AU - He, Xiao Peng

AU - Chen, Guo Rong

AU - James, Tony D.

AU - Li, Jia

PY - 2015/7/28

Y1 - 2015/7/28

N2 - With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.

AB - With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.

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UR - http://dx.doi.org/10.1039/c5cc04357c

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DO - 10.1039/c5cc04357c

M3 - Article

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SP - 11852

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JO - Chemical Communications

JF - Chemical Communications

IS - 59

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Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

Abstract

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