Glutamate-Dopamine Crosstalk in the Rat Prefrontal Cortex is Modulated by Alpha7 Nicotinic Receptors and Potentiated by PNU-120596

Philip D Livingstone, Jane A Dickinson, J Srinivasan, J N C Kew, Susan Wonnacott

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The aim of this study was to explore the modulation by α7 nicotinic receptors (nAChRs) of dopamine and glutamate release in the rat prefrontal cortex where these receptors are implicated in attentional processes and are therapeutic targets for cognitive deficits. The presence of presynaptic α7 nAChRs on glutamate terminals is supported by the ability of the subtype-selective agonist Compound A to evoke [3H]D-aspartate release from synaptosomes: This response was potentiated by the selective allosteric potentiator PNU-120596 and blocked by αbungarotoxin. Compound A also evoked dopamine overflow in the prefrontal cortex in vivo, and this was potentiated by PNU-120596. α7 nAChR-evoked [3H]dopamine release from tissue prisms in vitro was blocked by antagonists of NMDA and AMPA receptors. These data are consistent with a model in which α7 nAChRs present on glutamate terminals increase glutamate release that (1) contributes to presynaptic facilitation and synaptic plasticity and (2) co-ordinately enhances dopamine release from neighbouring boutons.
Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalJournal of Molecular Neuroscience
Volume40
Issue number1-2
DOIs
Publication statusPublished - 1 Jan 2010
Event13th International Symposium on Cholinergic Mechanisms 2008 - Foz do Iguacu, Brazil
Duration: 16 Aug 200820 Aug 2008
http://www.iscm2008.com.br/

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Nicotinic Receptors
Prefrontal Cortex
Glutamic Acid
Dopamine
D-Aspartic Acid
Neuronal Plasticity
AMPA Receptors
Synaptosomes
N-Methyl-D-Aspartate Receptors
1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea
Therapeutics

Cite this

Glutamate-Dopamine Crosstalk in the Rat Prefrontal Cortex is Modulated by Alpha7 Nicotinic Receptors and Potentiated by PNU-120596. / Livingstone, Philip D; Dickinson, Jane A; Srinivasan, J; Kew, J N C; Wonnacott, Susan.

In: Journal of Molecular Neuroscience, Vol. 40, No. 1-2, 01.01.2010, p. 172-176.

Research output: Contribution to journalArticle

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