Glucose selective Surface Plasmon Resonance-based bis-boronic acid sensor

Alex Stephenson-Brown, Hui-Chen Wang, Parvez Iqbal, Jon A. Preece, Yitao Long, John S. Fossey, Tony D. James, Paula M. Mendes

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Saccharides – a versatile class of biologically important molecules – are involved in a variety of physiological and pathological processes, but their detection and quantification is challenging. Herein, surface plasmon resonance and self-assembled monolayers on gold generated from bis-boronic acid bearing a thioctic acid moiety, whose intramolecular distance between the boronic acid moieties is well defined, are shown to detect D-glucose with high selectivity, demonstrating a higher affinity than other saccharides probed, namely D-galactose, D-fructose and D-mannose.
Original languageEnglish
Pages (from-to)7140-7145
Number of pages6
JournalAnalyst
Volume138
Issue number23
Early online date20 Nov 2013
DOIs
Publication statusPublished - 7 Dec 2013

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