Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

Ola B. Brynildsrud; Caitlin S. Pepperell; Philip Suffys; Louis Grandjean; Johana Monteserin; Nadia Debech; Jon Bohlin; Kristian Alfsnes; John O.H. Pettersson; Ingerid Kirkeleite; Fatima Fandinho; Marcia Aparecida Da Silva; Joao Perdigao; Isabel Portugal; Miguel Viveiros; Taane Clark; Maxine Caws; Sarah Dunstan; Phan Vuong Khac Thai; Beatriz Lopez; Viviana Ritacco; Andrew Kitchen; Tyler S. Brown; Dick Van Soolingen; Mary B. O'Neill; Kathryn E. Holt; Edward J. Feil; Barun Mathema; Francois Balloux; Vegard Eldholm

doi:10.1126/sciadv.aat5869

Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

Ola B. Brynildsrud, Caitlin S. Pepperell, Philip Suffys, Louis Grandjean, Johana Monteserin, Nadia Debech, Jon Bohlin, Kristian Alfsnes, John O.H. Pettersson, Ingerid Kirkeleite, Fatima Fandinho, Marcia Aparecida Da Silva, Joao Perdigao, Isabel Portugal, Miguel Viveiros, Taane Clark, Maxine Caws, Sarah Dunstan, Phan Vuong Khac Thai, Beatriz LopezViviana Ritacco, Andrew Kitchen, Tyler S. Brown, Dick Van Soolingen, Mary B. O'Neill, Kathryn E. Holt, Edward J. Feil, Barun Mathema, Francois Balloux, Vegard Eldholm

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Abstract

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.

Original language	English
Article number	eaat5869
Journal	Science Advances
Volume	4
Issue number	10
DOIs	https://doi.org/10.1126/sciadv.aat5869
Publication status	Published - 17 Oct 2018

Bibliographical note

Funding Information:
C.S.P. was supported by the NIH grant number 1R01AI113287-01A1. K.E.H. is funded by a Viertel Foundation of Australia Senior Medical Research Fellowship. F.B. acknowledges support from the BBSRC GCRF scheme and the National Institute for Health Research University College London Hospitals Biomedical Research Centre.

Publisher Copyright:
Copyright © 2018 The Authors, some rights reserved.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Funding

C.S.P. was supported by the NIH grant number 1R01AI113287-01A1. K.E.H. is funded by a Viertel Foundation of Australia Senior Medical Research Fellowship. F.B. acknowledges support from the BBSRC GCRF scheme and the National Institute for Health Research University College London Hospitals Biomedical Research Centre.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Brynildsrud, O. B., Pepperell, C. S., Suffys, P., Grandjean, L., Monteserin, J., Debech, N., Bohlin, J., Alfsnes, K., Pettersson, J. O. H., Kirkeleite, I., Fandinho, F., Da Silva, M. A., Perdigao, J., Portugal, I., Viveiros, M., Clark, T., Caws, M., Dunstan, S., Thai, P. V. K., ... Eldholm, V. (2018). Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation. Science Advances, 4(10), Article eaat5869. https://doi.org/10.1126/sciadv.aat5869

Brynildsrud, OB, Pepperell, CS, Suffys, P, Grandjean, L, Monteserin, J, Debech, N, Bohlin, J, Alfsnes, K, Pettersson, JOH, Kirkeleite, I, Fandinho, F, Da Silva, MA, Perdigao, J, Portugal, I, Viveiros, M, Clark, T, Caws, M, Dunstan, S, Thai, PVK, Lopez, B, Ritacco, V, Kitchen, A, Brown, TS, Van Soolingen, D, O'Neill, MB, Holt, KE, Feil, EJ, Mathema, B, Balloux, F & Eldholm, V 2018, 'Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation', Science Advances, vol. 4, no. 10, eaat5869. https://doi.org/10.1126/sciadv.aat5869

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abstract = "On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.",

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Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

UN SDGs

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