Glass microparticle‐ versus microsphere‐filled experimental dental adhesives

Ensanya A. Abou Neel, Azadeh Kiani, Sabeel Valappil, Nicky Mordan, Song-Yo Baek, Kazi M Zakir Hossain, Reda Felfel, Ifty Ahmed, Kamini Divakari, Wojciech Chrzanowski, Jonathan Knowles

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Abstract

This study aimed to formulate antibacterial dental adhesives. Phosphate‐substituted methacrylate adhesives were modified with 0–20 wt % copper‐doped glass microparticles. Two shapes of microparticles were used: regular shaped (microspheres) and irregular shaped (microparticles). The morphology/composition, roughness, monomer conversion (DC%), thermogravimetric analysis, and antibacterial action against S. mutans and P. aeruginosa and ion release were investigated. The results showed that microspheres produced adhesives with a relatively smoother surface than microparticles did. The DC% of adhesives increased with increasing glass filler content. Filled adhesives showed polymer decomposition at ~315 °C and glass melting at 600–1000 °C. The weight loss percent of adhesives decreased with increasing weight percent of fillers. Glass microparticles at 0–20 wt % significantly increased the antibacterial action of adhesives against both bacteria. Glass microspheres at 0–5 wt % significantly increased the antibacterial action of adhesives against both bacteria. Only 20 wt % microparticle‐filled adhesive showed an inhibition zone similar to tobramycin (positive control). Microparticle‐filled adhesives (with >5 wt % filler) significantly reduced S. mutans more than their microsphere counterparts. Microsphere‐filled adhesives (with ≤5 wt % filler) significantly reduced P. aeruginosa more than their microparticle counterparts. Microsphere‐filled adhesives showed higher Cu release than their microparticle counterparts. Accordingly, phosphate‐substituted methacrylate filled with glass could be used as an antibacterial adhesive.
Original languageEnglish
Article number47832
Pages (from-to)1-11
Number of pages11
JournalJournal of Applied Polymer Science
Volume136
Issue number32
Early online date22 Apr 2019
DOIs
Publication statusPublished - 20 Aug 2019

Keywords

  • adhesives
  • biomaterials
  • biomedical applications

ASJC Scopus subject areas

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Abou Neel, E. A., Kiani, A., Valappil, S., Mordan, N., Baek, S-Y., Hossain, K. M. Z., ... Knowles, J. (2019). Glass microparticle‐ versus microsphere‐filled experimental dental adhesives. Journal of Applied Polymer Science, 136(32), 1-11. [47832]. https://doi.org/10.1002/app.47832