Glass capillary microfluidics for production of monodispersed poly (dl-lactic acid) and polycaprolactone microparticles: Experiments and numerical simulations

Goran T. Vladisavljević, Hamed Shahmohamadi, Diganta B. Das, Ekanem E. Ekanem, Zhandos Tauanov, Lav Sharma

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Hypothesis: Droplet size in microfluidic devices is affected by wettability of the microfluidic channels. Three-dimensional countercurrent flow focusing using assemblies of chemically inert glass capillaries is expected to minimize wetting of the channel walls by the organic solvent. Experiments: Monodispersed polycaprolactone and poly(lactic acid) particles with a diameter of 18-150. μm were produced by evaporation of solvent (dichloromethane or 1:2 mixture of chloroform and toluene) from oil-in-water or water-in-oil-in-water emulsions produced in three-dimensional flow focusing glass capillary devices. The drop generation behaviour was simulated numerically using the volume of fluid method. Findings: The numerical results showed good agreement with high-speed video recordings. Monodispersed droplets were produced in the dripping regime when the ratio of the continuous phase flow rate to dispersed phase flow rate was 5-20 and the Weber number of the dispersed phase was less than 0.01. The porosity of polycaprolactone particles increased from 8 to 62% when 30. wt% of the water phase was incorporated in the organic phase prior to emulsification. The inner water phase was loaded with 0.156. wt% lidocaine hydrochloride to achieve a sustained drug release. 26% of lidocaine was released after 1. h and more than 93% of the drug was released after 130. h.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalJournal of Colloid and Interface Science
Volume418
DOIs
Publication statusPublished - 5 Mar 2014

Keywords

  • Computational fluid dynamics
  • Controlled drug release
  • Drop microfluidics
  • Flow focusing
  • Lidocaine hydrochloride
  • Monodispersed microparticle
  • Poly(lactic acid)
  • Polycaprolactone
  • Porous particle
  • Ultrasound contrast agent

ASJC Scopus subject areas

  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Glass capillary microfluidics for production of monodispersed poly (dl-lactic acid) and polycaprolactone microparticles: Experiments and numerical simulations'. Together they form a unique fingerprint.

Cite this