Genomic imprinting: CTCF protects the boundaries

Annabelle Lewis; Adele Murrell

doi:10.1016/j.cub.2004.03.026

Genomic imprinting: CTCF protects the boundaries

Annabelle Lewis, Adele Murrell

Research output: Contribution to journal › Review article › peer-review

77 Citations (SciVal)

Abstract

The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.

Original language	English
Pages (from-to)	R284-R286
Number of pages	3
Journal	Current Biology
Volume	14
Issue number	7
DOIs	https://doi.org/10.1016/j.cub.2004.03.026
Publication status	Published - 6 Apr 2004

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1016/j.cub.2004.03.026

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title = "Genomic imprinting: CTCF protects the boundaries",

abstract = "The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.",

author = "Annabelle Lewis and Adele Murrell",

year = "2004",

month = apr,

day = "6",

doi = "10.1016/j.cub.2004.03.026",

language = "English",

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TY - JOUR

T1 - Genomic imprinting

T2 - CTCF protects the boundaries

AU - Lewis, Annabelle

AU - Murrell, Adele

PY - 2004/4/6

Y1 - 2004/4/6

N2 - The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.

AB - The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.

UR - https://www.scopus.com/pages/publications/1842715884

U2 - 10.1016/j.cub.2004.03.026

DO - 10.1016/j.cub.2004.03.026

M3 - Review article

C2 - 15062124

AN - SCOPUS:1842715884

SN - 0960-9822

VL - 14

SP - R284-R286

JO - Current Biology

JF - Current Biology

IS - 7

ER -

Genomic imprinting: CTCF protects the boundaries

Abstract

ASJC Scopus subject areas

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