Abstract
The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.
Original language | English |
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Pages (from-to) | R284-R286 |
Number of pages | 3 |
Journal | Current Biology |
Volume | 14 |
Issue number | 7 |
DOIs | |
Publication status | Published - 6 Apr 2004 |
ASJC Scopus subject areas
- General Biochemistry,Genetics and Molecular Biology
- General Agricultural and Biological Sciences