Genomic imprinting: CTCF protects the boundaries

Annabelle Lewis, Adele Murrell

Research output: Contribution to journalReview articlepeer-review

75 Citations (SciVal)


The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.

Original languageEnglish
Pages (from-to)R284-R286
Number of pages3
JournalCurrent Biology
Issue number7
Publication statusPublished - 6 Apr 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)


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