Genomic imprinting and cancer: from primordial germ cells to somatic cells.

Adele Murrell

doi:10.1100/tsw.2006.318

Genomic imprinting and cancer: from primordial germ cells to somatic cells.

Adele Murrell

University of Cambridge

Research output: Contribution to journal › Review article › peer-review

36 Citations (SciVal)

Abstract

Imprinted genes are a subset of genes that are expressed from only one of the parental alleles. The majority of imprinted genes have roles in growth regulation and are, therefore, potential oncogenes or tumour suppressors. Cancer is a disease of aberrant cell growth and is characterised by genetic mutations and epigenetic changes such as DNA methylation. The mechanisms whereby imprinting is maintained in somatic cells and then erased and reset in the germline parallels epigenetic changes that cancer cells undergo. This review summarises what we know about imprinting in stem cells and how loss of imprinting may contribute to neoplasia.

Original language	English
Pages (from-to)	1888-1910
Number of pages	23
Journal	TheScientificWorldJournal
Volume	6
DOIs	https://doi.org/10.1100/tsw.2006.318
Publication status	Published - 1 May 2006

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
General Environmental Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1100/tsw.2006.318

Cite this

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AB - Imprinted genes are a subset of genes that are expressed from only one of the parental alleles. The majority of imprinted genes have roles in growth regulation and are, therefore, potential oncogenes or tumour suppressors. Cancer is a disease of aberrant cell growth and is characterised by genetic mutations and epigenetic changes such as DNA methylation. The mechanisms whereby imprinting is maintained in somatic cells and then erased and reset in the germline parallels epigenetic changes that cancer cells undergo. This review summarises what we know about imprinting in stem cells and how loss of imprinting may contribute to neoplasia.

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Genomic imprinting and cancer: from primordial germ cells to somatic cells.

Abstract

ASJC Scopus subject areas

UN SDGs

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