Genomic epidemiology of clinical Campylobacter spp. at a single health trust site

Steven J Dunn, Ben Pascoe, James Turton, Vicki Fleming, Mathew Diggle, Samuel K Sheppard, Alan McNally, Georgina Manning

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Campylobacter is the leading cause of bacterial enteritis in the developed world, and infections with the organism are largely sporadic in nature. Links between sporadic cases have not been established, with the majority of infections thought to be caused by genetically distinct isolates. Using a read-mapping approach, 158 clinical isolates collected during 2014 from the greater Nottinghamshire area were analysed to assess the local population structure and investigate potential case linkages between sporadic cases of campylobacteriosis. Four instances (2.5 %) of case linkage were observed across the dataset. This study demonstrates that case linkage does occur between sporadic Campylobacter infections, and provides evidence that a dual multi-locus sequence typing/within-lineage single nucleotide polymorphism typing approach to Campylobacter genomic epidemiology provides a benefit to public-health investigations.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalMicrobial Genomics
Volume4
Issue number10
Early online date11 Oct 2018
DOIs
Publication statusPublished - 11 Oct 2018

Keywords

  • Campylobacter
  • clinical
  • epidemiology
  • genomics
  • United Kingdom
  • WGS

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Genomic epidemiology of clinical Campylobacter spp. at a single health trust site'. Together they form a unique fingerprint.

  • Cite this