Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving

Katie L. Sealey, Simon R. Harris, Norman K. Fry, Laurence D. Hurst, Andrew R. Gorringe, Julian Parkhill, Andrew Preston

Research output: Contribution to journalArticle

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Abstract

A major outbreak of whooping cough, or pertussis, occurred in 2012 in the United Kingdom (UK), with nearly 10 000 laboratory-confirmed cases and 14 infant deaths attributed to pertussis. A worldwide resurgence of pertussis has been linked to switch to the use of acellular pertussis vaccines and the evolution of Bordetella pertussis away from vaccine-mediated immunity. We have conducted genomic analyses of multiple strains from the UK outbreak. We show that the UK outbreak was polyclonal in nature, caused by multiple distinct but closely related strains. Importantly, we demonstrate that acellular vaccine antigen-encoding genes are evolving at higher rates than other surface protein-encoding genes. This was true even prior to the introduction of pertussis vaccines but has become more pronounced since the introduction of the current acellular vaccines. The fast evolution of vaccine antigen-encoding genes has serious consequences for the ability of current vaccines to continue to control pertussis.

Original languageEnglish
Pages (from-to)294-301
Number of pages8
JournalJournal of Infectious Diseases
Volume212
Issue number2
Early online date8 Dec 2014
DOIs
Publication statusPublished - Jul 2015

Fingerprint

Whooping Cough
Disease Outbreaks
Acellular Vaccines
Pertussis Vaccine
Vaccines
Antigens
Genes
Bordetella pertussis
Immunity
Membrane Proteins
United Kingdom

Keywords

  • evolution
  • genomics
  • pertussis
  • vaccine

Cite this

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving. / Sealey, Katie L.; Harris, Simon R.; Fry, Norman K.; Hurst, Laurence D.; Gorringe, Andrew R.; Parkhill, Julian; Preston, Andrew.

In: Journal of Infectious Diseases, Vol. 212, No. 2, 07.2015, p. 294-301.

Research output: Contribution to journalArticle

Sealey, Katie L. ; Harris, Simon R. ; Fry, Norman K. ; Hurst, Laurence D. ; Gorringe, Andrew R. ; Parkhill, Julian ; Preston, Andrew. / Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving. In: Journal of Infectious Diseases. 2015 ; Vol. 212, No. 2. pp. 294-301.
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