Abstract
Mapping hybrid defects in contact zones between incipient species can identify genomic regions contributing to reproductive isolation and reveal genetic mechanisms of speciation. The house mouse features a rare combination of sophisticated genetic tools and natural hybrid zones between subspecies. Male hybrids often show reduced fertility, a common reproductive barrier between incipient species. Laboratory crosses have identified sterility loci, but each encompasses hundreds of genes. We map genetic determinants of testis weight and testis gene expression using offspring of mice captured in a hybrid zone between M. musculus musculus and M. m. domesticus. Many generations of admixture enables high-resolution mapping of loci contributing to these sterility-related phenotypes. We identify complex interactions among sterility loci, suggesting multiple, non-independent genetic incompatibilities contribute to barriers to gene flow in the hybrid zone.
| Original language | English |
|---|---|
| Article number | e02504 |
| Pages (from-to) | 1 |
| Number of pages | 1 |
| Journal | eLife |
| Volume | 3 |
| DOIs | |
| Publication status | Published - 9 Dec 2014 |
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Keywords
- Animals
- Chromosome Mapping
- Computer Simulation
- Epistasis, Genetic
- Genome
- Genome-Wide Association Study
- Hybridization, Genetic
- Infertility, Male
- Male
- Mice
- Models, Genetic
- Organ Size
- Phenotype
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- Testis
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
Cite this
Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions. / Turner, Leslie M.; Harr, Bettina.
In: eLife, Vol. 3, e02504, 09.12.2014, p. 1.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions
AU - Turner, Leslie M.
AU - Harr, Bettina
PY - 2014/12/9
Y1 - 2014/12/9
N2 - Mapping hybrid defects in contact zones between incipient species can identify genomic regions contributing to reproductive isolation and reveal genetic mechanisms of speciation. The house mouse features a rare combination of sophisticated genetic tools and natural hybrid zones between subspecies. Male hybrids often show reduced fertility, a common reproductive barrier between incipient species. Laboratory crosses have identified sterility loci, but each encompasses hundreds of genes. We map genetic determinants of testis weight and testis gene expression using offspring of mice captured in a hybrid zone between M. musculus musculus and M. m. domesticus. Many generations of admixture enables high-resolution mapping of loci contributing to these sterility-related phenotypes. We identify complex interactions among sterility loci, suggesting multiple, non-independent genetic incompatibilities contribute to barriers to gene flow in the hybrid zone.
AB - Mapping hybrid defects in contact zones between incipient species can identify genomic regions contributing to reproductive isolation and reveal genetic mechanisms of speciation. The house mouse features a rare combination of sophisticated genetic tools and natural hybrid zones between subspecies. Male hybrids often show reduced fertility, a common reproductive barrier between incipient species. Laboratory crosses have identified sterility loci, but each encompasses hundreds of genes. We map genetic determinants of testis weight and testis gene expression using offspring of mice captured in a hybrid zone between M. musculus musculus and M. m. domesticus. Many generations of admixture enables high-resolution mapping of loci contributing to these sterility-related phenotypes. We identify complex interactions among sterility loci, suggesting multiple, non-independent genetic incompatibilities contribute to barriers to gene flow in the hybrid zone.
KW - Animals
KW - Chromosome Mapping
KW - Computer Simulation
KW - Epistasis, Genetic
KW - Genome
KW - Genome-Wide Association Study
KW - Hybridization, Genetic
KW - Infertility, Male
KW - Male
KW - Mice
KW - Models, Genetic
KW - Organ Size
KW - Phenotype
KW - Polymorphism, Single Nucleotide
KW - Quantitative Trait Loci
KW - Testis
KW - Journal Article
KW - Research Support, N.I.H., Extramural
KW - Research Support, Non-U.S. Gov't
U2 - 10.7554/eLife.02504
DO - 10.7554/eLife.02504
M3 - Article
VL - 3
SP - 1
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e02504
ER -