Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions

Leslie M. Turner, Bettina Harr

Research output: Contribution to journalArticlepeer-review

73 Citations (SciVal)


Mapping hybrid defects in contact zones between incipient species can identify genomic regions contributing to reproductive isolation and reveal genetic mechanisms of speciation. The house mouse features a rare combination of sophisticated genetic tools and natural hybrid zones between subspecies. Male hybrids often show reduced fertility, a common reproductive barrier between incipient species. Laboratory crosses have identified sterility loci, but each encompasses hundreds of genes. We map genetic determinants of testis weight and testis gene expression using offspring of mice captured in a hybrid zone between M. musculus musculus and M. m. domesticus. Many generations of admixture enables high-resolution mapping of loci contributing to these sterility-related phenotypes. We identify complex interactions among sterility loci, suggesting multiple, non-independent genetic incompatibilities contribute to barriers to gene flow in the hybrid zone.

Original languageEnglish
Article numbere02504
Pages (from-to)1-1
Number of pages1
Publication statusPublished - 9 Dec 2014


  • Animals
  • Chromosome Mapping
  • Computer Simulation
  • Epistasis, Genetic
  • Genome
  • Genome-Wide Association Study
  • Hybridization, Genetic
  • Infertility, Male
  • Male
  • Mice
  • Models, Genetic
  • Organ Size
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci
  • Testis
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't


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