Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions

Leslie M. Turner, Bettina Harr

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Mapping hybrid defects in contact zones between incipient species can identify genomic regions contributing to reproductive isolation and reveal genetic mechanisms of speciation. The house mouse features a rare combination of sophisticated genetic tools and natural hybrid zones between subspecies. Male hybrids often show reduced fertility, a common reproductive barrier between incipient species. Laboratory crosses have identified sterility loci, but each encompasses hundreds of genes. We map genetic determinants of testis weight and testis gene expression using offspring of mice captured in a hybrid zone between M. musculus musculus and M. m. domesticus. Many generations of admixture enables high-resolution mapping of loci contributing to these sterility-related phenotypes. We identify complex interactions among sterility loci, suggesting multiple, non-independent genetic incompatibilities contribute to barriers to gene flow in the hybrid zone.

Original languageEnglish
Article numbere02504
Pages (from-to)1
Number of pages1
JournaleLife
Volume3
DOIs
Publication statusPublished - 9 Dec 2014

Fingerprint

Chromosome Mapping
Infertility
Genes
Gene expression
Testis
Genetic Speciation
Defects
Reproductive Isolation
Gene Flow
Fertility
Phenotype
Gene Expression
Weights and Measures

Keywords

  • Animals
  • Chromosome Mapping
  • Computer Simulation
  • Epistasis, Genetic
  • Genome
  • Genome-Wide Association Study
  • Hybridization, Genetic
  • Infertility, Male
  • Male
  • Mice
  • Models, Genetic
  • Organ Size
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci
  • Testis
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Cite this

Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions. / Turner, Leslie M.; Harr, Bettina.

In: eLife, Vol. 3, e02504, 09.12.2014, p. 1.

Research output: Contribution to journalArticle

@article{bcd9dbfbb2814dfea64fd38a01f42db0,
title = "Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions",
abstract = "Mapping hybrid defects in contact zones between incipient species can identify genomic regions contributing to reproductive isolation and reveal genetic mechanisms of speciation. The house mouse features a rare combination of sophisticated genetic tools and natural hybrid zones between subspecies. Male hybrids often show reduced fertility, a common reproductive barrier between incipient species. Laboratory crosses have identified sterility loci, but each encompasses hundreds of genes. We map genetic determinants of testis weight and testis gene expression using offspring of mice captured in a hybrid zone between M. musculus musculus and M. m. domesticus. Many generations of admixture enables high-resolution mapping of loci contributing to these sterility-related phenotypes. We identify complex interactions among sterility loci, suggesting multiple, non-independent genetic incompatibilities contribute to barriers to gene flow in the hybrid zone.",
keywords = "Animals, Chromosome Mapping, Computer Simulation, Epistasis, Genetic, Genome, Genome-Wide Association Study, Hybridization, Genetic, Infertility, Male, Male, Mice, Models, Genetic, Organ Size, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Testis, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Turner, {Leslie M.} and Bettina Harr",
year = "2014",
month = "12",
day = "9",
doi = "10.7554/eLife.02504",
language = "English",
volume = "3",
pages = "1",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

TY - JOUR

T1 - Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions

AU - Turner, Leslie M.

AU - Harr, Bettina

PY - 2014/12/9

Y1 - 2014/12/9

N2 - Mapping hybrid defects in contact zones between incipient species can identify genomic regions contributing to reproductive isolation and reveal genetic mechanisms of speciation. The house mouse features a rare combination of sophisticated genetic tools and natural hybrid zones between subspecies. Male hybrids often show reduced fertility, a common reproductive barrier between incipient species. Laboratory crosses have identified sterility loci, but each encompasses hundreds of genes. We map genetic determinants of testis weight and testis gene expression using offspring of mice captured in a hybrid zone between M. musculus musculus and M. m. domesticus. Many generations of admixture enables high-resolution mapping of loci contributing to these sterility-related phenotypes. We identify complex interactions among sterility loci, suggesting multiple, non-independent genetic incompatibilities contribute to barriers to gene flow in the hybrid zone.

AB - Mapping hybrid defects in contact zones between incipient species can identify genomic regions contributing to reproductive isolation and reveal genetic mechanisms of speciation. The house mouse features a rare combination of sophisticated genetic tools and natural hybrid zones between subspecies. Male hybrids often show reduced fertility, a common reproductive barrier between incipient species. Laboratory crosses have identified sterility loci, but each encompasses hundreds of genes. We map genetic determinants of testis weight and testis gene expression using offspring of mice captured in a hybrid zone between M. musculus musculus and M. m. domesticus. Many generations of admixture enables high-resolution mapping of loci contributing to these sterility-related phenotypes. We identify complex interactions among sterility loci, suggesting multiple, non-independent genetic incompatibilities contribute to barriers to gene flow in the hybrid zone.

KW - Animals

KW - Chromosome Mapping

KW - Computer Simulation

KW - Epistasis, Genetic

KW - Genome

KW - Genome-Wide Association Study

KW - Hybridization, Genetic

KW - Infertility, Male

KW - Male

KW - Mice

KW - Models, Genetic

KW - Organ Size

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

KW - Testis

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.7554/eLife.02504

DO - 10.7554/eLife.02504

M3 - Article

VL - 3

SP - 1

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e02504

ER -