TY - JOUR
T1 - Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation
AU - Kikuchi, Taisei
AU - Dayi, Mehmet
AU - Hunt, Vicky L.
AU - Ishiwata, Kenji
AU - Toyoda, Atsushi
AU - Kounosu, Asuka
AU - Sun, Simo
AU - Maeda, Yasunobu
AU - Kondo, Yoko
AU - de Noya, Belkisyole Alarcon
AU - Noya, Oscar
AU - Kojima, Somei
AU - Kuramochi, Toshiaki
AU - Maruyama, Haruhiko
N1 - Funding Information:
Genome data analyses were partly performed using the DDBJ supercomputer system. We thank Ryusei Tanaka, Akemi Yoshida for assistance and comments. This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Numbers 26460510 and 19H03212, AMED 18fk0108009h0003 and JST CREST Grant Number JPMJCR18S7.
Publisher Copyright:
© 2021, The Author(s).
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/12/31
Y1 - 2021/12/31
N2 - The cryptic parasite Sparganum proliferum proliferates in humans and invades tissues and organs. Only scattered cases have been reported, but S. proliferum infection is always fatal. However, S. proliferum’s phylogeny and life cycle remain enigmatic. To investigate the phylogenetic relationships between S. proliferum and other cestode species, and to examine the mechanisms underlying pathogenicity, we sequenced the entire genomes of S. proliferum and a closely related non–life-threatening tapeworm Spirometra erinaceieuropaei. Additionally, we performed larvae transcriptome analyses of S. proliferum plerocercoid to identify genes involved in asexual reproduction in the host. The genome sequences confirmed that the S. proliferum has experienced a clearly distinct evolutionary history from S. erinaceieuropaei. Moreover, we found that nonordinal extracellular matrix coordination allows asexual reproduction in the host, and loss of sexual maturity in S. proliferum are responsible for its fatal pathogenicity to humans. Our high-quality reference genome sequences should be valuable for future studies of pseudophyllidean tapeworm biology and parasitism.
AB - The cryptic parasite Sparganum proliferum proliferates in humans and invades tissues and organs. Only scattered cases have been reported, but S. proliferum infection is always fatal. However, S. proliferum’s phylogeny and life cycle remain enigmatic. To investigate the phylogenetic relationships between S. proliferum and other cestode species, and to examine the mechanisms underlying pathogenicity, we sequenced the entire genomes of S. proliferum and a closely related non–life-threatening tapeworm Spirometra erinaceieuropaei. Additionally, we performed larvae transcriptome analyses of S. proliferum plerocercoid to identify genes involved in asexual reproduction in the host. The genome sequences confirmed that the S. proliferum has experienced a clearly distinct evolutionary history from S. erinaceieuropaei. Moreover, we found that nonordinal extracellular matrix coordination allows asexual reproduction in the host, and loss of sexual maturity in S. proliferum are responsible for its fatal pathogenicity to humans. Our high-quality reference genome sequences should be valuable for future studies of pseudophyllidean tapeworm biology and parasitism.
UR - http://www.scopus.com/inward/record.url?scp=85107343266&partnerID=8YFLogxK
U2 - 10.1038/s42003-021-02160-8
DO - 10.1038/s42003-021-02160-8
M3 - Article
C2 - 34059788
AN - SCOPUS:85107343266
SN - 2399-3642
VL - 4
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 649
ER -