Abstract
The molecular processes that underlie addiction are beginning to unfold. Genetically determined variations in dopaminergic neurotransmission predispose to nicotine dependence. In addition, tobacco use is likely to be governed by the rate at which smokers metabolize nicotine. Functional polymorphisms in cytochrome P450 monooxygenases that metabolize nicotine have now been defined and it should soon be possible to identify fast nicotine metabolizers by DNA analysis. Here, we review the key neurotransmitter receptors and metabolic enzymes implicated in tobacco dependence. We explore the potential benefits of classifying smokers according to the molecular aetiology of their habit. One major benefit will be in planning effective strategies for smoking cessation. Methods of typing for alleles related to smoking behavior that might be suitable for use in clinical practice in the future will also be discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 70-76 |
| Number of pages | 7 |
| Journal | Trends in Molecular Medicine |
| Volume | 7 |
| Issue number | 2 |
| Early online date | 22 Feb 2001 |
| DOIs | |
| Publication status | Published - Feb 2001 |
Acknowledgements
This work was supported by the Imperial Cancer Research Fund and the University of Oxford. We are greateful to an anonymous reviewer for helpful comments and to Dr Michael Murphy for help and advice in discussing the concepts represented in the article.ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
