Genes involved in forebrain development in the zebrafish, Danio rerio

C P Heisenberg, M Brand, Y J Jiang, R M Warga, D Beuchle, F J M vanEeden, Makoto Furutani-Seiki, M Granato, P Haffter, M Hammerschmidt, D A Kane, R N Kelsh, M C Mullins, J Odenthal, C NussleinVolhard

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Abstract

We identified four zebrafish mutants with defects in forebrain induction and patterning during embryogenesis. The four mutants define three genes: masterblind (mbl), silverblick (slb), and knollnase (kas), In mbl embryos, the anterior forebrain acquires posterior forebrain characteristics: anterior structures such as the eyes, olfactory placodes and the telencephalon are missing, whereas the epiphysis located in the posterior forebrain is expanded, In slb embryos, the extension of the embryonic axis is initially delayed and eventually followed by a partial fusion of the eyes, Finally, in kas embryos, separation of the telencephalic primordia is incomplete and dorsal midline cells fail to form a differentiated roof plate, Analysis of the mutant phenotypes indicates that we have identified genes essential for the specification of the anterior forebrain (mbl), positioning of the eyes (slb) and differentiation of the roof plate (kas). In an appendix to this study we list mutants showing alterations in the size of the eyes and abnormal differentiation of the lenses.
LanguageEnglish
Pages191-203
Number of pages13
JournalDevelopment
Volume123
StatusPublished - 1996

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Zebrafish
Prosencephalon
Telencephalon
Embryonic Structures
Genes
Epiphyses
Essential Genes
Lenses
Embryonic Development
Phenotype

Keywords

  • Danio rerio
  • forebrain
  • neurogenesis
  • zebrafish
  • lens
  • eye
  • neural development

Cite this

Heisenberg, C. P., Brand, M., Jiang, Y. J., Warga, R. M., Beuchle, D., vanEeden, F. J. M., ... NussleinVolhard, C. (1996). Genes involved in forebrain development in the zebrafish, Danio rerio.

Genes involved in forebrain development in the zebrafish, Danio rerio. / Heisenberg, C P; Brand, M; Jiang, Y J; Warga, R M; Beuchle, D; vanEeden, F J M; Furutani-Seiki, Makoto; Granato, M; Haffter, P; Hammerschmidt, M; Kane, D A; Kelsh, R N; Mullins, M C; Odenthal, J; NussleinVolhard, C.

In: Development, Vol. 123, 1996, p. 191-203.

Research output: Contribution to journalArticle

Heisenberg, CP, Brand, M, Jiang, YJ, Warga, RM, Beuchle, D, vanEeden, FJM, Furutani-Seiki, M, Granato, M, Haffter, P, Hammerschmidt, M, Kane, DA, Kelsh, RN, Mullins, MC, Odenthal, J & NussleinVolhard, C 1996, 'Genes involved in forebrain development in the zebrafish, Danio rerio' Development, vol. 123, pp. 191-203.
Heisenberg CP, Brand M, Jiang YJ, Warga RM, Beuchle D, vanEeden FJM et al. Genes involved in forebrain development in the zebrafish, Danio rerio. Development. 1996;123:191-203.
Heisenberg, C P ; Brand, M ; Jiang, Y J ; Warga, R M ; Beuchle, D ; vanEeden, F J M ; Furutani-Seiki, Makoto ; Granato, M ; Haffter, P ; Hammerschmidt, M ; Kane, D A ; Kelsh, R N ; Mullins, M C ; Odenthal, J ; NussleinVolhard, C. / Genes involved in forebrain development in the zebrafish, Danio rerio. In: Development. 1996 ; Vol. 123. pp. 191-203
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abstract = "We identified four zebrafish mutants with defects in forebrain induction and patterning during embryogenesis. The four mutants define three genes: masterblind (mbl), silverblick (slb), and knollnase (kas), In mbl embryos, the anterior forebrain acquires posterior forebrain characteristics: anterior structures such as the eyes, olfactory placodes and the telencephalon are missing, whereas the epiphysis located in the posterior forebrain is expanded, In slb embryos, the extension of the embryonic axis is initially delayed and eventually followed by a partial fusion of the eyes, Finally, in kas embryos, separation of the telencephalic primordia is incomplete and dorsal midline cells fail to form a differentiated roof plate, Analysis of the mutant phenotypes indicates that we have identified genes essential for the specification of the anterior forebrain (mbl), positioning of the eyes (slb) and differentiation of the roof plate (kas). In an appendix to this study we list mutants showing alterations in the size of the eyes and abnormal differentiation of the lenses.",
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AB - We identified four zebrafish mutants with defects in forebrain induction and patterning during embryogenesis. The four mutants define three genes: masterblind (mbl), silverblick (slb), and knollnase (kas), In mbl embryos, the anterior forebrain acquires posterior forebrain characteristics: anterior structures such as the eyes, olfactory placodes and the telencephalon are missing, whereas the epiphysis located in the posterior forebrain is expanded, In slb embryos, the extension of the embryonic axis is initially delayed and eventually followed by a partial fusion of the eyes, Finally, in kas embryos, separation of the telencephalic primordia is incomplete and dorsal midline cells fail to form a differentiated roof plate, Analysis of the mutant phenotypes indicates that we have identified genes essential for the specification of the anterior forebrain (mbl), positioning of the eyes (slb) and differentiation of the roof plate (kas). In an appendix to this study we list mutants showing alterations in the size of the eyes and abnormal differentiation of the lenses.

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