Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis

Eleni M Tomazou; Vardhman K Rakyan; Gregory Lefebvre; Robert Andrews; Peter Ellis; David K Jackson; Cordelia Langford; Matthew D Francis; Liselotte Bäckdahl; Marcos Miretti; Penny Coggill; Diego Ottaviani; Denise Sheer; Adele Murrell; Stephan Beck

doi:10.1186/1755-8794-1-19

Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis

Eleni M Tomazou, Vardhman K Rakyan, Gregory Lefebvre, Robert Andrews, Peter Ellis, David K Jackson, Cordelia Langford, Matthew D Francis, Liselotte Bäckdahl, Marcos Miretti, Penny Coggill, Diego Ottaviani, Denise Sheer, Adele Murrell, Stephan Beck

Department of Life Sciences

Wellcome Sanger Institute

Research output: Contribution to journal › Article › peer-review

Abstract

The major histocompatibility complex (MHC) is essential for human immunity and is highly associated with common diseases, including cancer. While the genetics of the MHC has been studied intensively for many decades, very little is known about the epigenetics of this most polymorphic and disease-associated region of the genome.

Original language	English
Article number	19
Journal	BMC Medical Genomics
Volume	1
DOIs	https://doi.org/10.1186/1755-8794-1-19
Publication status	Published - 2008

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1186/1755-8794-1-19

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Tomazou, E. M., Rakyan, V. K., Lefebvre, G., Andrews, R., Ellis, P., Jackson, D. K., Langford, C., Francis, M. D., Bäckdahl, L., Miretti, M., Coggill, P., Ottaviani, D., Sheer, D., Murrell, A., & Beck, S. (2008). Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis. BMC Medical Genomics, 1, Article 19. https://doi.org/10.1186/1755-8794-1-19

Tomazou, EM, Rakyan, VK, Lefebvre, G, Andrews, R, Ellis, P, Jackson, DK, Langford, C, Francis, MD, Bäckdahl, L, Miretti, M, Coggill, P, Ottaviani, D, Sheer, D, Murrell, A & Beck, S 2008, 'Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis', BMC Medical Genomics, vol. 1, 19. https://doi.org/10.1186/1755-8794-1-19

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abstract = "The major histocompatibility complex (MHC) is essential for human immunity and is highly associated with common diseases, including cancer. While the genetics of the MHC has been studied intensively for many decades, very little is known about the epigenetics of this most polymorphic and disease-associated region of the genome.",

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AU - Tomazou, Eleni M

AU - Rakyan, Vardhman K

AU - Lefebvre, Gregory

AU - Andrews, Robert

AU - Ellis, Peter

AU - Jackson, David K

AU - Langford, Cordelia

AU - Francis, Matthew D

AU - Bäckdahl, Liselotte

AU - Miretti, Marcos

AU - Coggill, Penny

AU - Ottaviani, Diego

AU - Sheer, Denise

AU - Murrell, Adele

AU - Beck, Stephan

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AB - The major histocompatibility complex (MHC) is essential for human immunity and is highly associated with common diseases, including cancer. While the genetics of the MHC has been studied intensively for many decades, very little is known about the epigenetics of this most polymorphic and disease-associated region of the genome.

UR - http://dx.doi.org/10.1186/1755-8794-1-19

U2 - 10.1186/1755-8794-1-19

DO - 10.1186/1755-8794-1-19

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C2 - 18513384

SN - 1755-8794

SN - 1471-2350

VL - 1

JO - BMC Medical Genomics

JF - BMC Medical Genomics

M1 - 19

ER -

Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis

Abstract

UN SDGs

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