Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis

Eleni M Tomazou, Vardhman K Rakyan, Gregory Lefebvre, Robert Andrews, Peter Ellis, David K Jackson, Cordelia Langford, Matthew D Francis, Liselotte Bäckdahl, Marcos Miretti, Penny Coggill, Diego Ottaviani, Denise Sheer, Adele Murrell, Stephan Beck

Research output: Contribution to journalArticlepeer-review

Abstract

The major histocompatibility complex (MHC) is essential for human immunity and is highly associated with common diseases, including cancer. While the genetics of the MHC has been studied intensively for many decades, very little is known about the epigenetics of this most polymorphic and disease-associated region of the genome.
Original languageEnglish
Article number19
JournalBMC Medical Genomics
Volume1
DOIs
Publication statusPublished - 2008

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