Abstract

The development of self-powered wearable biodevices is highly attractive for a number of applications, such as health monitoring and drug delivery. Enzymatic fuel cells (EFCs) hold great potential as power sources for such devices, since they can generate power from physiological fluids and operate at body temperature.

In this study, we present a cascade of three EFCs embedded in a compact and handy single channel device and we demonstrate for the first time power generation from iontophoresis extracts obtained from pig skin. The EFCs implement non-toxic highly-porous gold electrodes; an easy-to-reproduce procedure is adopted for the immobilization of glucose oxidase and laccase at the anode and cathode respectively; no external mediators are used; and the system design can easily be further miniaturized.

When electrically connected in parallel, the EFCs generated a power output close to the sum of the power generated by each unit, with peak values of 0.7 µW (flow-through mode) and 0.4 µW (batch mode), at a glucose concentration of 27 mM. When the device was fed with transdermal extracts, containing only 30 μM of glucose, the average peak power was proportionally lower (0.004 µW).
LanguageEnglish
Pages411-417
JournalBiosensors and Bioelectronics
Volume78
Early online date28 Nov 2015
DOIs
StatusPublished - 15 Apr 2016

Fingerprint

Enzymatic fuel cells
Electrodes
Equipment and Supplies
Glucose
Electric Power Supplies
Laccase
Iontophoresis
Glucose Oxidase
Drug Monitoring
Body Temperature
Immobilization
Gold
Glucose oxidase
Swine
Drug delivery
Power generation
Skin
Anodes
Cathodes
Systems analysis

Keywords

  • Enzymatic fuel cell; Glucose oxidase; Laccase; Highly porous gold; Reverse iontophoresis

Cite this

@article{6c6c9be44c474363a42efd71278f1684,
title = "Generating power from transdermal extracts using a multi-electrode miniature enzymatic fuel cell",
abstract = "The development of self-powered wearable biodevices is highly attractive for a number of applications, such as health monitoring and drug delivery. Enzymatic fuel cells (EFCs) hold great potential as power sources for such devices, since they can generate power from physiological fluids and operate at body temperature.In this study, we present a cascade of three EFCs embedded in a compact and handy single channel device and we demonstrate for the first time power generation from iontophoresis extracts obtained from pig skin. The EFCs implement non-toxic highly-porous gold electrodes; an easy-to-reproduce procedure is adopted for the immobilization of glucose oxidase and laccase at the anode and cathode respectively; no external mediators are used; and the system design can easily be further miniaturized.When electrically connected in parallel, the EFCs generated a power output close to the sum of the power generated by each unit, with peak values of 0.7 µW (flow-through mode) and 0.4 µW (batch mode), at a glucose concentration of 27 mM. When the device was fed with transdermal extracts, containing only 30 μM of glucose, the average peak power was proportionally lower (0.004 µW).",
keywords = "Enzymatic fuel cell; Glucose oxidase; Laccase; Highly porous gold; Reverse iontophoresis",
author = "{Du Toit}, Hendrik and Rashidi, {Razleen B.} and Ferdani, {Dominic W.} and Delgado-Charro, {Maria Begona} and Sangan, {Carl M.} and {Di Lorenzo}, Mirella",
year = "2016",
month = "4",
day = "15",
doi = "10.1016/j.bios.2015.11.074",
language = "English",
volume = "78",
pages = "411--417",
journal = "Biosensors and Bioelectronics",
issn = "0956-5663",
publisher = "Elsevier",

}

TY - JOUR

T1 - Generating power from transdermal extracts using a multi-electrode miniature enzymatic fuel cell

AU - Du Toit,Hendrik

AU - Rashidi,Razleen B.

AU - Ferdani,Dominic W.

AU - Delgado-Charro,Maria Begona

AU - Sangan,Carl M.

AU - Di Lorenzo,Mirella

PY - 2016/4/15

Y1 - 2016/4/15

N2 - The development of self-powered wearable biodevices is highly attractive for a number of applications, such as health monitoring and drug delivery. Enzymatic fuel cells (EFCs) hold great potential as power sources for such devices, since they can generate power from physiological fluids and operate at body temperature.In this study, we present a cascade of three EFCs embedded in a compact and handy single channel device and we demonstrate for the first time power generation from iontophoresis extracts obtained from pig skin. The EFCs implement non-toxic highly-porous gold electrodes; an easy-to-reproduce procedure is adopted for the immobilization of glucose oxidase and laccase at the anode and cathode respectively; no external mediators are used; and the system design can easily be further miniaturized.When electrically connected in parallel, the EFCs generated a power output close to the sum of the power generated by each unit, with peak values of 0.7 µW (flow-through mode) and 0.4 µW (batch mode), at a glucose concentration of 27 mM. When the device was fed with transdermal extracts, containing only 30 μM of glucose, the average peak power was proportionally lower (0.004 µW).

AB - The development of self-powered wearable biodevices is highly attractive for a number of applications, such as health monitoring and drug delivery. Enzymatic fuel cells (EFCs) hold great potential as power sources for such devices, since they can generate power from physiological fluids and operate at body temperature.In this study, we present a cascade of three EFCs embedded in a compact and handy single channel device and we demonstrate for the first time power generation from iontophoresis extracts obtained from pig skin. The EFCs implement non-toxic highly-porous gold electrodes; an easy-to-reproduce procedure is adopted for the immobilization of glucose oxidase and laccase at the anode and cathode respectively; no external mediators are used; and the system design can easily be further miniaturized.When electrically connected in parallel, the EFCs generated a power output close to the sum of the power generated by each unit, with peak values of 0.7 µW (flow-through mode) and 0.4 µW (batch mode), at a glucose concentration of 27 mM. When the device was fed with transdermal extracts, containing only 30 μM of glucose, the average peak power was proportionally lower (0.004 µW).

KW - Enzymatic fuel cell; Glucose oxidase; Laccase; Highly porous gold; Reverse iontophoresis

UR - http://dx.doi.org/10.1016/j.bios.2015.11.074

UR - http://dx.doi.org/10.1016/j.bios.2015.11.074

U2 - 10.1016/j.bios.2015.11.074

DO - 10.1016/j.bios.2015.11.074

M3 - Article

VL - 78

SP - 411

EP - 417

JO - Biosensors and Bioelectronics

T2 - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

SN - 0956-5663

ER -