TY - JOUR
T1 - Gene Loss and Lineage-Specific Restriction-Modification Systems Associated with Niche Differentiation in the Campylobacter jejuni Sequence Type 403 Clonal Complex
AU - Morley, Laura
AU - McNally, Alan
AU - Paszkiewicz, Konrad
AU - Corander, Jukka
AU - Méric, Guillaume
AU - Sheppard, Samuel K
AU - Blom, Jochen
AU - Manning, Georgina
N1 - Copyright © 2015, American Society for Microbiology. All Rights Reserved.
PY - 2015/6
Y1 - 2015/6
N2 - Campylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages commonly found in poultry, livestock, and human disease cases to host-adapted specialized lineages primarily associated with livestock or poultry. Here, we present novel data on the ST403 clonal complex of C. jejuni, a lineage that has not been reported in avian hosts. Our data show that the lineage exhibits a distinctive pattern of intralineage recombination that is accompanied by the presence of lineage-specific restriction-modification systems. Furthermore, we show that the ST403 complex has undergone gene decay at a number of loci. Our data provide a putative link between the lack of association with avian hosts of C. jejuni ST403 and both gene gain and gene loss through nonsense mutations in coding sequences of genes, resulting in pseudogene formation.
AB - Campylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages commonly found in poultry, livestock, and human disease cases to host-adapted specialized lineages primarily associated with livestock or poultry. Here, we present novel data on the ST403 clonal complex of C. jejuni, a lineage that has not been reported in avian hosts. Our data show that the lineage exhibits a distinctive pattern of intralineage recombination that is accompanied by the presence of lineage-specific restriction-modification systems. Furthermore, we show that the ST403 complex has undergone gene decay at a number of loci. Our data provide a putative link between the lack of association with avian hosts of C. jejuni ST403 and both gene gain and gene loss through nonsense mutations in coding sequences of genes, resulting in pseudogene formation.
KW - Animals
KW - Campylobacter Infections
KW - Campylobacter jejuni
KW - Codon, Nonsense
KW - DNA Restriction-Modification Enzymes
KW - Evolution, Molecular
KW - Gene Deletion
KW - Multilocus Sequence Typing
KW - Poultry
KW - Recombination, Genetic
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
UR - https://doi.org/10.1128/AEM.00546-15
U2 - 10.1128/AEM.00546-15
DO - 10.1128/AEM.00546-15
M3 - Article
C2 - 25795671
SN - 0099-2240
VL - 81
SP - 3641
EP - 3647
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
IS - 11
ER -