Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex.

Peter V Massey, E C Warburton, D Wynick, M W Brown, Z I Bashir

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast however, there is no deficit in single item object recognition memory, a memory that depends on perirhinal cortex. Furthermore, in perirhinal cortex slices there are no differences in activity-dependent long-term potentiation or depotentiation, nor in muscarinic receptor-dependent long-term depression between galanin knockout mice and wild-type litter-mates. Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory.
Original languageEnglish
Pages (from-to)40-48
Number of pages9
JournalNeuropharmacology
Volume44
Issue number1
DOIs
Publication statusPublished - 2003

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