Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex.

Peter V Massey, E C Warburton, D Wynick, M W Brown, Z I Bashir

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast however, there is no deficit in single item object recognition memory, a memory that depends on perirhinal cortex. Furthermore, in perirhinal cortex slices there are no differences in activity-dependent long-term potentiation or depotentiation, nor in muscarinic receptor-dependent long-term depression between galanin knockout mice and wild-type litter-mates. Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory.
Original languageEnglish
Pages (from-to)40-48
Number of pages9
JournalNeuropharmacology
Volume44
Issue number1
DOIs
Publication statusPublished - 2003

Fingerprint

Galanin
Neuronal Plasticity
Knockout Mice
Long-Term Synaptic Depression
Long-Term Potentiation
Muscarinic Receptors
Neuropeptides
Depression
Recognition (Psychology)
Spatial Memory
Perirhinal Cortex

Cite this

Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex. / Massey, Peter V; Warburton, E C; Wynick, D; Brown, M W; Bashir, Z I.

In: Neuropharmacology, Vol. 44, No. 1, 2003, p. 40-48.

Research output: Contribution to journalArticle

Massey, Peter V ; Warburton, E C ; Wynick, D ; Brown, M W ; Bashir, Z I. / Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex. In: Neuropharmacology. 2003 ; Vol. 44, No. 1. pp. 40-48.
@article{5cae9a18d5e44babb2ee4f663ec51018,
title = "Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex.",
abstract = "It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast however, there is no deficit in single item object recognition memory, a memory that depends on perirhinal cortex. Furthermore, in perirhinal cortex slices there are no differences in activity-dependent long-term potentiation or depotentiation, nor in muscarinic receptor-dependent long-term depression between galanin knockout mice and wild-type litter-mates. Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory.",
author = "Massey, {Peter V} and Warburton, {E C} and D Wynick and Brown, {M W} and Bashir, {Z I}",
note = "ID number: PMID: 12559120",
year = "2003",
doi = "10.1016/S0028-3908(02)00297-6",
language = "English",
volume = "44",
pages = "40--48",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex.

AU - Massey, Peter V

AU - Warburton, E C

AU - Wynick, D

AU - Brown, M W

AU - Bashir, Z I

N1 - ID number: PMID: 12559120

PY - 2003

Y1 - 2003

N2 - It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast however, there is no deficit in single item object recognition memory, a memory that depends on perirhinal cortex. Furthermore, in perirhinal cortex slices there are no differences in activity-dependent long-term potentiation or depotentiation, nor in muscarinic receptor-dependent long-term depression between galanin knockout mice and wild-type litter-mates. Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory.

AB - It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast however, there is no deficit in single item object recognition memory, a memory that depends on perirhinal cortex. Furthermore, in perirhinal cortex slices there are no differences in activity-dependent long-term potentiation or depotentiation, nor in muscarinic receptor-dependent long-term depression between galanin knockout mice and wild-type litter-mates. Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory.

UR - http://dx.doi.org/10.1016/S0028-3908(02)00297-6

U2 - 10.1016/S0028-3908(02)00297-6

DO - 10.1016/S0028-3908(02)00297-6

M3 - Article

VL - 44

SP - 40

EP - 48

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 1

ER -