Fungal G-protein-coupled receptors: mediators of pathogenesis and targets for disease control

Neil Brown, Sanne Schrevens, Patrick van Dijck, Gustavo Goldman

Research output: Contribution to journalReview article

18 Citations (Scopus)
178 Downloads (Pure)

Abstract

G-protein signalling pathways are involved in sensing the environment, enabling fungi to coordinate cell function, metabolism and development with their surroundings, thereby promoting their survival, propagation and virulence. G-protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in fungi. Despite the apparent importance of GPCR signalling to fungal biology and virulence, relatively few GPCR–G-protein interactions, and even fewer receptor-binding ligands, have been identified. Approximately 40% of current pharmaceuticals target human GPCRs, due to their cell surface location and central role in cell signalling. Fungal GPCRs do not belong to any of the mammalian receptor classes, making them druggable targets for antifungal development. This Review Article evaluates developments in our understanding of fungal GPCR-mediated signalling, while substantiating the rationale for considering these receptors as potential antifungal targets. The need for insights into the structure–function relationship of receptor–ligand interactions is highlighted, which could facilitate the development of receptor-interfering compounds that could be used in disease control.
Original languageEnglish
Pages (from-to)402–414
Number of pages13
JournalNature Microbiology
Volume3
Early online date27 Mar 2018
DOIs
Publication statusPublished - 1 Apr 2018

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Genetics
  • Microbiology (medical)
  • Cell Biology

Fingerprint Dive into the research topics of 'Fungal G-protein-coupled receptors: mediators of pathogenesis and targets for disease control'. Together they form a unique fingerprint.

  • Profiles

    Cite this