Abstract
Traditional methods in microbiology applied for drug discovery focus on investigating microorganisms in monoculture, thereby separating these organisms from their habitat including accompanying microorganisms. Recent studies have indicated that intra- and interspecies communication can trigger the production of silent gene clusters leading to novel compounds. Many of them are believed to have functions as infochemicals in microbial communication. Thus, co-cultivation of microorganisms represents a promising approach to discover novel antibacterial and antifungal compounds in the involved species. Here, we summarise the recent development on fungal - streptomycete interactions successfully applied to wakening fungal secondary metabolite gene clusters and isolating novel natural products. This edition first published 2014
| Original language | English |
|---|---|
| Title of host publication | Natural Products |
| Subtitle of host publication | Discourse, Diversity, and Design |
| Editors | A. Osbourn, R. Goss, G. T. Carter |
| Publisher | Wiley-Blackwell |
| Pages | 147-158 |
| Number of pages | 12 |
| ISBN (Electronic) | 9781118794623 |
| ISBN (Print) | 9781118298060 |
| DOIs | |
| Publication status | Published - 5 May 2014 |
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Keywords
- Chromatin-based gene regulation
- Fungal secondary metabolism gene clusters
- Fungal-actinomycete interactions
- Interorganismic interactions
- Microbial regulatory interactions
ASJC Scopus subject areas
- Immunology and Microbiology(all)
Cite this
Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions. / Schroeckh, Volker; Nützmann, Hans Wilhelm; Brakhage, Axel A.
Natural Products: Discourse, Diversity, and Design. ed. / A. Osbourn; R. Goss; G. T. Carter. Wiley-Blackwell, 2014. p. 147-158.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions
AU - Schroeckh, Volker
AU - Nützmann, Hans Wilhelm
AU - Brakhage, Axel A.
PY - 2014/5/5
Y1 - 2014/5/5
N2 - Traditional methods in microbiology applied for drug discovery focus on investigating microorganisms in monoculture, thereby separating these organisms from their habitat including accompanying microorganisms. Recent studies have indicated that intra- and interspecies communication can trigger the production of silent gene clusters leading to novel compounds. Many of them are believed to have functions as infochemicals in microbial communication. Thus, co-cultivation of microorganisms represents a promising approach to discover novel antibacterial and antifungal compounds in the involved species. Here, we summarise the recent development on fungal - streptomycete interactions successfully applied to wakening fungal secondary metabolite gene clusters and isolating novel natural products. This edition first published 2014
AB - Traditional methods in microbiology applied for drug discovery focus on investigating microorganisms in monoculture, thereby separating these organisms from their habitat including accompanying microorganisms. Recent studies have indicated that intra- and interspecies communication can trigger the production of silent gene clusters leading to novel compounds. Many of them are believed to have functions as infochemicals in microbial communication. Thus, co-cultivation of microorganisms represents a promising approach to discover novel antibacterial and antifungal compounds in the involved species. Here, we summarise the recent development on fungal - streptomycete interactions successfully applied to wakening fungal secondary metabolite gene clusters and isolating novel natural products. This edition first published 2014
KW - Chromatin-based gene regulation
KW - Fungal secondary metabolism gene clusters
KW - Fungal-actinomycete interactions
KW - Interorganismic interactions
KW - Microbial regulatory interactions
UR - http://www.scopus.com/inward/record.url?scp=84926455617&partnerID=8YFLogxK
U2 - 10.1002/9781118794623.ch8
DO - 10.1002/9781118794623.ch8
M3 - Chapter
SN - 9781118298060
SP - 147
EP - 158
BT - Natural Products
A2 - Osbourn, A.
A2 - Goss, R.
A2 - Carter, G. T.
PB - Wiley-Blackwell
ER -