Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions

Volker Schroeckh, Hans Wilhelm Nützmann, Axel A. Brakhage

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Traditional methods in microbiology applied for drug discovery focus on investigating microorganisms in monoculture, thereby separating these organisms from their habitat including accompanying microorganisms. Recent studies have indicated that intra- and interspecies communication can trigger the production of silent gene clusters leading to novel compounds. Many of them are believed to have functions as infochemicals in microbial communication. Thus, co-cultivation of microorganisms represents a promising approach to discover novel antibacterial and antifungal compounds in the involved species. Here, we summarise the recent development on fungal - streptomycete interactions successfully applied to wakening fungal secondary metabolite gene clusters and isolating novel natural products. This edition first published 2014

Original languageEnglish
Title of host publicationNatural Products
Subtitle of host publicationDiscourse, Diversity, and Design
EditorsA. Osbourn, R. Goss, G. T. Carter
PublisherWiley-Blackwell
Pages147-158
Number of pages12
ISBN (Electronic)9781118794623
ISBN (Print)9781118298060
DOIs
Publication statusPublished - 5 May 2014

Keywords

  • Chromatin-based gene regulation
  • Fungal secondary metabolism gene clusters
  • Fungal-actinomycete interactions
  • Interorganismic interactions
  • Microbial regulatory interactions

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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    Schroeckh, V., Nützmann, H. W., & Brakhage, A. A. (2014). Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions. In A. Osbourn, R. Goss, & G. T. Carter (Eds.), Natural Products: Discourse, Diversity, and Design (pp. 147-158). Wiley-Blackwell. https://doi.org/10.1002/9781118794623.ch8