Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions

Volker Schroeckh, Hans Wilhelm Nützmann, Axel A. Brakhage

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Traditional methods in microbiology applied for drug discovery focus on investigating microorganisms in monoculture, thereby separating these organisms from their habitat including accompanying microorganisms. Recent studies have indicated that intra- and interspecies communication can trigger the production of silent gene clusters leading to novel compounds. Many of them are believed to have functions as infochemicals in microbial communication. Thus, co-cultivation of microorganisms represents a promising approach to discover novel antibacterial and antifungal compounds in the involved species. Here, we summarise the recent development on fungal - streptomycete interactions successfully applied to wakening fungal secondary metabolite gene clusters and isolating novel natural products. This edition first published 2014

Original languageEnglish
Title of host publicationNatural Products
Subtitle of host publicationDiscourse, Diversity, and Design
EditorsA. Osbourn, R. Goss, G. T. Carter
PublisherWiley-Blackwell
Pages147-158
Number of pages12
ISBN (Electronic)9781118794623
ISBN (Print)9781118298060
DOIs
Publication statusPublished - 5 May 2014

Fingerprint

Secondary Metabolism
Actinobacteria
Multigene Family
Drug Discovery
Microbiology
Biological Products
Ecosystem

Keywords

  • Chromatin-based gene regulation
  • Fungal secondary metabolism gene clusters
  • Fungal-actinomycete interactions
  • Interorganismic interactions
  • Microbial regulatory interactions

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Schroeckh, V., Nützmann, H. W., & Brakhage, A. A. (2014). Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions. In A. Osbourn, R. Goss, & G. T. Carter (Eds.), Natural Products: Discourse, Diversity, and Design (pp. 147-158). Wiley-Blackwell. https://doi.org/10.1002/9781118794623.ch8

Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions. / Schroeckh, Volker; Nützmann, Hans Wilhelm; Brakhage, Axel A.

Natural Products: Discourse, Diversity, and Design. ed. / A. Osbourn; R. Goss; G. T. Carter. Wiley-Blackwell, 2014. p. 147-158.

Research output: Chapter in Book/Report/Conference proceedingChapter

Schroeckh, V, Nützmann, HW & Brakhage, AA 2014, Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions. in A Osbourn, R Goss & GT Carter (eds), Natural Products: Discourse, Diversity, and Design. Wiley-Blackwell, pp. 147-158. https://doi.org/10.1002/9781118794623.ch8
Schroeckh V, Nützmann HW, Brakhage AA. Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions. In Osbourn A, Goss R, Carter GT, editors, Natural Products: Discourse, Diversity, and Design. Wiley-Blackwell. 2014. p. 147-158 https://doi.org/10.1002/9781118794623.ch8
Schroeckh, Volker ; Nützmann, Hans Wilhelm ; Brakhage, Axel A. / Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions. Natural Products: Discourse, Diversity, and Design. editor / A. Osbourn ; R. Goss ; G. T. Carter. Wiley-Blackwell, 2014. pp. 147-158
@inbook{18315c10da7e484596d7cc77974ac84d,
title = "Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions",
abstract = "Traditional methods in microbiology applied for drug discovery focus on investigating microorganisms in monoculture, thereby separating these organisms from their habitat including accompanying microorganisms. Recent studies have indicated that intra- and interspecies communication can trigger the production of silent gene clusters leading to novel compounds. Many of them are believed to have functions as infochemicals in microbial communication. Thus, co-cultivation of microorganisms represents a promising approach to discover novel antibacterial and antifungal compounds in the involved species. Here, we summarise the recent development on fungal - streptomycete interactions successfully applied to wakening fungal secondary metabolite gene clusters and isolating novel natural products. This edition first published 2014",
keywords = "Chromatin-based gene regulation, Fungal secondary metabolism gene clusters, Fungal-actinomycete interactions, Interorganismic interactions, Microbial regulatory interactions",
author = "Volker Schroeckh and N{\"u}tzmann, {Hans Wilhelm} and Brakhage, {Axel A.}",
year = "2014",
month = "5",
day = "5",
doi = "10.1002/9781118794623.ch8",
language = "English",
isbn = "9781118298060",
pages = "147--158",
editor = "A. Osbourn and R. Goss and Carter, {G. T.}",
booktitle = "Natural Products",
publisher = "Wiley-Blackwell",
address = "USA United States",

}

TY - CHAP

T1 - Fungal-Actinomycete Interactions - Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions

AU - Schroeckh, Volker

AU - Nützmann, Hans Wilhelm

AU - Brakhage, Axel A.

PY - 2014/5/5

Y1 - 2014/5/5

N2 - Traditional methods in microbiology applied for drug discovery focus on investigating microorganisms in monoculture, thereby separating these organisms from their habitat including accompanying microorganisms. Recent studies have indicated that intra- and interspecies communication can trigger the production of silent gene clusters leading to novel compounds. Many of them are believed to have functions as infochemicals in microbial communication. Thus, co-cultivation of microorganisms represents a promising approach to discover novel antibacterial and antifungal compounds in the involved species. Here, we summarise the recent development on fungal - streptomycete interactions successfully applied to wakening fungal secondary metabolite gene clusters and isolating novel natural products. This edition first published 2014

AB - Traditional methods in microbiology applied for drug discovery focus on investigating microorganisms in monoculture, thereby separating these organisms from their habitat including accompanying microorganisms. Recent studies have indicated that intra- and interspecies communication can trigger the production of silent gene clusters leading to novel compounds. Many of them are believed to have functions as infochemicals in microbial communication. Thus, co-cultivation of microorganisms represents a promising approach to discover novel antibacterial and antifungal compounds in the involved species. Here, we summarise the recent development on fungal - streptomycete interactions successfully applied to wakening fungal secondary metabolite gene clusters and isolating novel natural products. This edition first published 2014

KW - Chromatin-based gene regulation

KW - Fungal secondary metabolism gene clusters

KW - Fungal-actinomycete interactions

KW - Interorganismic interactions

KW - Microbial regulatory interactions

UR - http://www.scopus.com/inward/record.url?scp=84926455617&partnerID=8YFLogxK

U2 - 10.1002/9781118794623.ch8

DO - 10.1002/9781118794623.ch8

M3 - Chapter

SN - 9781118298060

SP - 147

EP - 158

BT - Natural Products

A2 - Osbourn, A.

A2 - Goss, R.

A2 - Carter, G. T.

PB - Wiley-Blackwell

ER -