Fundamental processes in the evolutionary ecology of Lyme borreliosis

Klaus Kurtenbach, Klára Hanincová, Jean I Tsao, Gabriele Margos, Durland Fish, Nicholas H Ogden

Research output: Contribution to journalArticle

366 Citations (SciVal)


The evolutionary ecology of many emerging infectious diseases, particularly vector-borne zoonoses, is poorly understood. Here, we aim to develop a biological, process-based framework for vector-borne zoonoses, using Borrelia burgdorferi sensu lato (s.l.), the causative agent of Lyme borreliosis in humans, as an example. We explore the fundamental biological processes that operate in this zoonosis and put forward hypotheses on how extrinsic cues and intrinsic dynamics shape B. burgdorferi s.l. populations. Additionally, we highlight possible epidemiological parallels between B. burgdorferi s.l. and other vector-borne zoonotic pathogens, including West Nile virus.
Original languageEnglish
Pages (from-to)660-669
Number of pages10
JournalNature Reviews Microbiology
Issue number9
Publication statusPublished - Sept 2006


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