Functionalising reagents and their uses

Andrew Watts (Inventor), Terrence Kantner (Inventor), Amanda Mackenzie (Inventor)

Research output: Patent

Abstract

Reagents and methods for functionalising polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly (alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly (alkylene glycol) molecule and/or the glycan group.
Original languageEnglish
Patent numberCN102317305 (A)
Publication statusPublished - 11 Jan 2012

Fingerprint

Glycols
Sulfhydryl Compounds
Polysaccharides
Peptides
Molecules
Cysteine
Nitrogen

Cite this

Watts, A., Kantner, T., & Mackenzie, A. (2012). Functionalising reagents and their uses. (Patent No. CN102317305 (A)).

Functionalising reagents and their uses. / Watts, Andrew (Inventor); Kantner, Terrence (Inventor); Mackenzie, Amanda (Inventor).

Patent No.: CN102317305 (A).

Research output: Patent

Watts, A, Kantner, T & Mackenzie, A 2012, Functionalising reagents and their uses, Patent No. CN102317305 (A).
Watts A, Kantner T, Mackenzie A, inventors. Functionalising reagents and their uses. CN102317305 (A). 2012 Jan 11.
Watts, Andrew (Inventor) ; Kantner, Terrence (Inventor) ; Mackenzie, Amanda (Inventor). / Functionalising reagents and their uses. Patent No.: CN102317305 (A).
@misc{da98abcf22b448c6b3a63868cd3e73ad,
title = "Functionalising reagents and their uses",
abstract = "Reagents and methods for functionalising polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly (alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly (alkylene glycol) molecule and/or the glycan group.",
author = "Andrew Watts and Terrence Kantner and Amanda Mackenzie",
year = "2012",
month = "1",
day = "11",
language = "English",
type = "Patent",
note = "CN102317305 (A)",

}

TY - PAT

T1 - Functionalising reagents and their uses

AU - Watts, Andrew

AU - Kantner, Terrence

AU - Mackenzie, Amanda

PY - 2012/1/11

Y1 - 2012/1/11

N2 - Reagents and methods for functionalising polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly (alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly (alkylene glycol) molecule and/or the glycan group.

AB - Reagents and methods for functionalising polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly (alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly (alkylene glycol) molecule and/or the glycan group.

M3 - Patent

M1 - CN102317305 (A)

ER -