Functional proteomic biomarkers in cancer

Banafshe Larijani, Michela Perani, Kholoud Alburai'si, Peter J Parker

Research output: Contribution to journalArticle

Abstract

Beyond penetrant germline and somatic mutations, there are substantial challenges in extrapolating phenotypes from linear DNA sequences and transcriptomics. This brings a molecular pathology emphasis to the properties of the main players responsible for executing actions, proteins. The proteomic attribute most frequently determined in pathology is (relative) content, but for many candidate biomarkers this is not the most important feature to understand. In keeping pace with the depth of knowledge of the mechanisms underlying pathologies, we need to ask more sophisticated questions about the state of proteins, for example, their oligomerization status, modification status, and location. This demands hitherto nonroutine approaches to proteomics, which we will discuss in this brief perspective.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1346
Issue number1
DOIs
Publication statusPublished - Jun 2015

Keywords

  • Biomarkers, Tumor/analysis
  • Fluorescence Resonance Energy Transfer
  • Gene Expression Regulation, Neoplastic
  • Gene Regulatory Networks
  • Humans
  • Neoplasms/diagnosis
  • Proteomics/methods

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