From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?

Nicholas K. Priest, Justine K. Rudkin, Edward J. Feil, Jean M. H. Van Den Elsen, Ambrose Cheung, Sharon J. Peacock, Maisem Laabei, David A. Lucks, Mario Recker, Ruth C. Massey

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

With the advent of high-throughput whole-genome sequencing, it is now possible to sequence a bacterial genome in a matter of hours. However, although the presence or absence of a particular gene can be determined, we do not yet have the tools to extract information about the true virulence potential of an organism from sequence data alone. Here, we focus on the important human pathogen Staphylococcus aureus and present a framework for the construction of a broad systems biology-based tool that could be used to predict virulence phenotypes from S. aureus genomic sequences using existing technology.
Original languageEnglish
Pages (from-to)791-797
Number of pages7
JournalNature Reviews Microbiology
Volume10
Issue number11
Early online date16 Oct 2012
DOIs
Publication statusPublished - Nov 2012

Fingerprint

Systems Biology
Virulence
Staphylococcus aureus
Genotype
Phenotype
Bacterial Genomes
Genome
Technology
Genes

Cite this

From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence? / Priest, Nicholas K.; Rudkin, Justine K.; Feil, Edward J.; Van Den Elsen, Jean M. H.; Cheung, Ambrose; Peacock, Sharon J.; Laabei, Maisem; Lucks, David A.; Recker, Mario; Massey, Ruth C.

In: Nature Reviews Microbiology, Vol. 10, No. 11, 11.2012, p. 791-797.

Research output: Contribution to journalReview article

Priest, Nicholas K. ; Rudkin, Justine K. ; Feil, Edward J. ; Van Den Elsen, Jean M. H. ; Cheung, Ambrose ; Peacock, Sharon J. ; Laabei, Maisem ; Lucks, David A. ; Recker, Mario ; Massey, Ruth C. / From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?. In: Nature Reviews Microbiology. 2012 ; Vol. 10, No. 11. pp. 791-797.
@article{0c5e82fb3c1b4148beb4b6574936c644,
title = "From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?",
abstract = "With the advent of high-throughput whole-genome sequencing, it is now possible to sequence a bacterial genome in a matter of hours. However, although the presence or absence of a particular gene can be determined, we do not yet have the tools to extract information about the true virulence potential of an organism from sequence data alone. Here, we focus on the important human pathogen Staphylococcus aureus and present a framework for the construction of a broad systems biology-based tool that could be used to predict virulence phenotypes from S. aureus genomic sequences using existing technology.",
author = "Priest, {Nicholas K.} and Rudkin, {Justine K.} and Feil, {Edward J.} and {Van Den Elsen}, {Jean M. H.} and Ambrose Cheung and Peacock, {Sharon J.} and Maisem Laabei and Lucks, {David A.} and Mario Recker and Massey, {Ruth C.}",
year = "2012",
month = "11",
doi = "10.1038/nrmicro2880",
language = "English",
volume = "10",
pages = "791--797",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?

AU - Priest, Nicholas K.

AU - Rudkin, Justine K.

AU - Feil, Edward J.

AU - Van Den Elsen, Jean M. H.

AU - Cheung, Ambrose

AU - Peacock, Sharon J.

AU - Laabei, Maisem

AU - Lucks, David A.

AU - Recker, Mario

AU - Massey, Ruth C.

PY - 2012/11

Y1 - 2012/11

N2 - With the advent of high-throughput whole-genome sequencing, it is now possible to sequence a bacterial genome in a matter of hours. However, although the presence or absence of a particular gene can be determined, we do not yet have the tools to extract information about the true virulence potential of an organism from sequence data alone. Here, we focus on the important human pathogen Staphylococcus aureus and present a framework for the construction of a broad systems biology-based tool that could be used to predict virulence phenotypes from S. aureus genomic sequences using existing technology.

AB - With the advent of high-throughput whole-genome sequencing, it is now possible to sequence a bacterial genome in a matter of hours. However, although the presence or absence of a particular gene can be determined, we do not yet have the tools to extract information about the true virulence potential of an organism from sequence data alone. Here, we focus on the important human pathogen Staphylococcus aureus and present a framework for the construction of a broad systems biology-based tool that could be used to predict virulence phenotypes from S. aureus genomic sequences using existing technology.

UR - http://www.scopus.com/inward/record.url?scp=84867800804&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1038/nmicro2880

U2 - 10.1038/nrmicro2880

DO - 10.1038/nrmicro2880

M3 - Review article

VL - 10

SP - 791

EP - 797

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

IS - 11

ER -