From evaporative to cooling crystallisation: an initial co-crystallisation study of cytosine and its fluorinated derivative with 4-chloro-3,5-dinitrobenzoic acid

Kate Wittering, Josh King, Lynne H. Thomas, Chick C. Wilson

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
155 Downloads (Pure)

Abstract

Two new multi-component molecular complexes of cytosine and 5-fluorocytosine with 4-chloro-3,5-dinitrobenzoic acid are presented. Materials synthesis was achieved initially by evaporative crystallisation and the crystal structures determined. The process was then successfully transferred into a controlled small scale cooling crystallisation environment, with bulk samples shown to be representative of the multi-component product phase, by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) methods. Turbidity measurements are shown to be a valuable process analytical technology probe for characterising the initial stages of molecular complex formation in solution. The significance of these findings for scale-up of crystallisation of multi-component molecular materials and for future transfer into continuous cooling crystallisation is discussed.
Original languageEnglish
Pages (from-to)123-140
Number of pages18
JournalCrystals
Volume4
Issue number2
DOIs
Publication statusPublished - 11 Jun 2014

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