Projects per year
Abstract
Two new multi-component molecular complexes of cytosine and 5-fluorocytosine with 4-chloro-3,5-dinitrobenzoic acid are presented. Materials synthesis was achieved initially by evaporative crystallisation and the crystal structures determined. The process was then successfully transferred into a controlled small scale cooling crystallisation environment, with bulk samples shown to be representative of the multi-component product phase, by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) methods. Turbidity measurements are shown to be a valuable process analytical technology probe for characterising the initial stages of molecular complex formation in solution. The significance of these findings for scale-up of crystallisation of multi-component molecular materials and for future transfer into continuous cooling crystallisation is discussed.
Original language | English |
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Pages (from-to) | 123-140 |
Number of pages | 18 |
Journal | Crystals |
Volume | 4 |
Issue number | 2 |
DOIs | |
Publication status | Published - 11 Jun 2014 |
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Dive into the research topics of 'From evaporative to cooling crystallisation: an initial co-crystallisation study of cytosine and its fluorinated derivative with 4-chloro-3,5-dinitrobenzoic acid'. Together they form a unique fingerprint.Projects
- 1 Finished
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Centre for Innovative Manufacturing and Crystallisation
Wilson, C. (PI)
Engineering and Physical Sciences Research Council
1/10/11 → 31/12/16
Project: Research council