From early markers to neuro-developmental mechanisms of autism

T. Gliga, E.j.h. Jones, R. Bedford, T. Charman, M. H. Johnson

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

A fast growing field, the study of infants at risk because of having an older sibling with autism (i.e. infant sibs) aims to identify the earliest signs of this disorder, which would allow for earlier diagnosis and intervention. More importantly, we argue, these studies offer the opportunity to validate existing neuro-developmental models of autism against experimental evidence. Although autism is mainly seen as a disorder of social interaction and communication, emerging early markers do not exclusively reflect impairments of the "social brain". Evidence for atypical development of sensory and attentional systems highlight the need to move away from localized deficits to models suggesting brain-wide involvement in autism pathology. We discuss the implications infant sibs findings have for future work into the biology of autism and the development of interventions.
Original languageEnglish
Pages (from-to)189-207
Number of pages19
JournalDevelopmental Review
Volume34
Issue number3
Early online date11 Jun 2014
DOIs
Publication statusPublished - 1 Sep 2014

Keywords

  • Infants
  • Autism
  • The "social brain"
  • Sensory processing
  • SPECTRUM DISORDERS
  • EXECUTIVE FUNCTION
  • SOCIAL-PERCEPTION
  • JOINT ATTENTION
  • YOUNG-CHILDREN
  • EYE-GAZE
  • COMMUNICATION DIFFICULTIES
  • FUNCTIONAL CONNECTIVITY
  • ORBITOFRONTAL CORTEX
  • BIOLOGICAL MOTION

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