Friendly foes: the evolution of host protection by a parasite

Ben Ashby, Kayla King

Research output: Contribution to journalArticle

Abstract

Hosts are often infected by multiple parasite species, yet the ecological and evolutionary implications of the interactions between hosts and coinfecting parasites are largely unknown. Most theoretical models of evolution among coinfecting parasites focus on the evolution of virulence, but parasites may also evolve to protect their hosts by reducing susceptibility (i.e. conferring resistance) to other parasites or reducing the virulence of coinfecting parasites (i.e. conferring tolerance). Here, we analyse the eco-evolutionary dynamics of parasite-conferred resistance and tolerance using coinfection models. We show that both parasite-conferred resistance and tolerance can evolve for a wide range of underlying trade-offs. The shape and strength of the trade-off qualitatively affects the outcome causing shifts between the minimisation or maximisation of protection, intermediate stable strategies, evolutionary branching, and bistability. Furthermore, we find that a protected dimorphism can readily evolve for parasite-conferred resistance, but find no evidence of evolutionary branching for parasite-conferred tolerance, in general agreement with previous work on host evolution. These results provide novel insights into the evolution of parasite-conferred resistance and tolerance, and suggest clues to the underlying trade-offs in recent experimental work on microbe-mediated protection. More generally, our results highlight the context dependence of host-parasite relationships in complex communities.
LanguageEnglish
Pages211-221
JournalEvolution Letters
Volume1
Issue number4
DOIs
StatusPublished - 31 Aug 2017

Fingerprint

Tolerance
parasite
parasite resistance
parasites
tolerance
Trade-offs
Branching
virulence
Evolutionary Strategy
Evolutionary Dynamics
Bistability
Susceptibility
Theoretical Model
branching
Resistance
Parasites
dimorphism
Unknown
trade-off
host-parasite relationships

Keywords

  • host-parasite systems
  • defensive mutualism
  • evolution
  • resistance
  • tolerance

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Applied Mathematics
  • Modelling and Simulation

Cite this

Friendly foes: the evolution of host protection by a parasite. / Ashby, Ben; King, Kayla.

In: Evolution Letters, Vol. 1, No. 4, 31.08.2017, p. 211-221.

Research output: Contribution to journalArticle

Ashby, Ben ; King, Kayla. / Friendly foes: the evolution of host protection by a parasite. In: Evolution Letters. 2017 ; Vol. 1, No. 4. pp. 211-221
@article{556cadb10c654f2fa1ce8d9251e98efb,
title = "Friendly foes: the evolution of host protection by a parasite",
abstract = "Hosts are often infected by multiple parasite species, yet the ecological and evolutionary implications of the interactions between hosts and coinfecting parasites are largely unknown. Most theoretical models of evolution among coinfecting parasites focus on the evolution of virulence, but parasites may also evolve to protect their hosts by reducing susceptibility (i.e. conferring resistance) to other parasites or reducing the virulence of coinfecting parasites (i.e. conferring tolerance). Here, we analyse the eco-evolutionary dynamics of parasite-conferred resistance and tolerance using coinfection models. We show that both parasite-conferred resistance and tolerance can evolve for a wide range of underlying trade-offs. The shape and strength of the trade-off qualitatively affects the outcome causing shifts between the minimisation or maximisation of protection, intermediate stable strategies, evolutionary branching, and bistability. Furthermore, we find that a protected dimorphism can readily evolve for parasite-conferred resistance, but find no evidence of evolutionary branching for parasite-conferred tolerance, in general agreement with previous work on host evolution. These results provide novel insights into the evolution of parasite-conferred resistance and tolerance, and suggest clues to the underlying trade-offs in recent experimental work on microbe-mediated protection. More generally, our results highlight the context dependence of host-parasite relationships in complex communities.",
keywords = "host-parasite systems, defensive mutualism, evolution, resistance, tolerance",
author = "Ben Ashby and Kayla King",
year = "2017",
month = "8",
day = "31",
doi = "10.1002/evl3.19",
language = "English",
volume = "1",
pages = "211--221",
journal = "Evolution Letters",
issn = "2056-3744",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Friendly foes: the evolution of host protection by a parasite

AU - Ashby,Ben

AU - King,Kayla

PY - 2017/8/31

Y1 - 2017/8/31

N2 - Hosts are often infected by multiple parasite species, yet the ecological and evolutionary implications of the interactions between hosts and coinfecting parasites are largely unknown. Most theoretical models of evolution among coinfecting parasites focus on the evolution of virulence, but parasites may also evolve to protect their hosts by reducing susceptibility (i.e. conferring resistance) to other parasites or reducing the virulence of coinfecting parasites (i.e. conferring tolerance). Here, we analyse the eco-evolutionary dynamics of parasite-conferred resistance and tolerance using coinfection models. We show that both parasite-conferred resistance and tolerance can evolve for a wide range of underlying trade-offs. The shape and strength of the trade-off qualitatively affects the outcome causing shifts between the minimisation or maximisation of protection, intermediate stable strategies, evolutionary branching, and bistability. Furthermore, we find that a protected dimorphism can readily evolve for parasite-conferred resistance, but find no evidence of evolutionary branching for parasite-conferred tolerance, in general agreement with previous work on host evolution. These results provide novel insights into the evolution of parasite-conferred resistance and tolerance, and suggest clues to the underlying trade-offs in recent experimental work on microbe-mediated protection. More generally, our results highlight the context dependence of host-parasite relationships in complex communities.

AB - Hosts are often infected by multiple parasite species, yet the ecological and evolutionary implications of the interactions between hosts and coinfecting parasites are largely unknown. Most theoretical models of evolution among coinfecting parasites focus on the evolution of virulence, but parasites may also evolve to protect their hosts by reducing susceptibility (i.e. conferring resistance) to other parasites or reducing the virulence of coinfecting parasites (i.e. conferring tolerance). Here, we analyse the eco-evolutionary dynamics of parasite-conferred resistance and tolerance using coinfection models. We show that both parasite-conferred resistance and tolerance can evolve for a wide range of underlying trade-offs. The shape and strength of the trade-off qualitatively affects the outcome causing shifts between the minimisation or maximisation of protection, intermediate stable strategies, evolutionary branching, and bistability. Furthermore, we find that a protected dimorphism can readily evolve for parasite-conferred resistance, but find no evidence of evolutionary branching for parasite-conferred tolerance, in general agreement with previous work on host evolution. These results provide novel insights into the evolution of parasite-conferred resistance and tolerance, and suggest clues to the underlying trade-offs in recent experimental work on microbe-mediated protection. More generally, our results highlight the context dependence of host-parasite relationships in complex communities.

KW - host-parasite systems

KW - defensive mutualism

KW - evolution

KW - resistance

KW - tolerance

UR - https://doi.org/10.1002/evl3.19

U2 - 10.1002/evl3.19

DO - 10.1002/evl3.19

M3 - Article

VL - 1

SP - 211

EP - 221

JO - Evolution Letters

T2 - Evolution Letters

JF - Evolution Letters

SN - 2056-3744

IS - 4

ER -