Fluorescent probes and functional materials for biomedical applications

Xi Le Hu, Hui Qi Gan, Fan-De Meng, Hai Hao Han, De-Tai Shi, Shu Zhang, Lei Zou, Xiao-Peng He, Tony James

Research output: Contribution to journalReview articlepeer-review

13 Citations (SciVal)


Due to their simplicity in preparation, sensitivity and selectivity, fluorescent probes have become the analytical tool of choice in a wide range of research and industrial fields, facilitating the rapid detection of chemical substances of interest as well as the study of important physiological and pathological processes at the cellular level. In addition, many long-wavelength fluorescent probes developed have also proven applicable for in vivo biomedical applications including fluorescence-guided disease diagnosis and theranostics (e.g., fluorogenic prodrugs). Impressive progresses have been made in the development of sensing agents and materials for the detection of ions, organic small molecules, and biomacromolecules including enzymes, DNAs/RNAs, lipids, and carbohydrates that play crucial roles in biological and disease-relevant events. Here, we highlight examples of fluorescent probes and functional materials for biological applications selected from the special issues “Fluorescent Probes” and “Molecular Sensors and Logic Gates” recently published in this journal, offering insights into the future development of powerful fluorescence-based chemical tools for basic biological studies and clinical translation.

Original languageEnglish
Pages (from-to)1425-1437
Number of pages13
JournalFrontiers of Chemical Science and Engineering
Issue number10
Early online date18 May 2022
Publication statusPublished - 31 Oct 2022


  • biomedicine
  • biomolecules
  • cell
  • fluorescent probes
  • imaging

ASJC Scopus subject areas

  • Chemical Engineering(all)


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