Fluorescent probes and functional materials for biomedical applications

Xi Le Hu; Hui Qi Gan; Fan-De  Meng; Hai Hao Han; De-Tai Shi; Shu  Zhang; Lei  Zou; Xiao-Peng He; Tony James

doi:10.1007/s11705-022-2163-1

Fluorescent probes and functional materials for biomedical applications

Xi Le Hu, Hui Qi Gan, Fan-De Meng, Hai Hao Han, De-Tai Shi, Shu Zhang, Lei Zou, Xiao-Peng He, Tony James

Research output: Contribution to journal › Review article › peer-review

14 Citations (SciVal)

Abstract

Due to their simplicity in preparation, sensitivity and selectivity, fluorescent probes have become the analytical tool of choice in a wide range of research and industrial fields, facilitating the rapid detection of chemical substances of interest as well as the study of important physiological and pathological processes at the cellular level. In addition, many long-wavelength fluorescent probes developed have also proven applicable for in vivo biomedical applications including fluorescence-guided disease diagnosis and theranostics (e.g., fluorogenic prodrugs). Impressive progresses have been made in the development of sensing agents and materials for the detection of ions, organic small molecules, and biomacromolecules including enzymes, DNAs/RNAs, lipids, and carbohydrates that play crucial roles in biological and disease-relevant events. Here, we highlight examples of fluorescent probes and functional materials for biological applications selected from the special issues “Fluorescent Probes” and “Molecular Sensors and Logic Gates” recently published in this journal, offering insights into the future development of powerful fluorescence-based chemical tools for basic biological studies and clinical translation.

Original language	English
Pages (from-to)	1425-1437
Number of pages	13
Journal	Frontiers of Chemical Science and Engineering
Volume	16
Issue number	10
Early online date	18 May 2022
DOIs	https://doi.org/10.1007/s11705-022-2163-1
Publication status	Published - 31 Oct 2022

Bibliographical note

Funding Information:
The authors thank the National Natural Science Foundation of China (Grant Nos. 21907030 and 22108077) and the International Cooperation Program of Shanghai Science and Technology Committee (Grant No. 19410712600). De-Tai Shi would like to thank the Natural Science Foundation of Jiangxi (Grant No. 20161BAB213067) and the Scientific Research Fund of Jiangxi Provincial Education Department (Grant No. GJJ170807). Tony D. James wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (Grant No. 2020ZD01).

Keywords

biomedicine
biomolecules
cell
fluorescent probes
imaging

ASJC Scopus subject areas

General Chemical Engineering

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10.1007/s11705-022-2163-1Licence: CC BY

Cite this

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abstract = "Due to their simplicity in preparation, sensitivity and selectivity, fluorescent probes have become the analytical tool of choice in a wide range of research and industrial fields, facilitating the rapid detection of chemical substances of interest as well as the study of important physiological and pathological processes at the cellular level. In addition, many long-wavelength fluorescent probes developed have also proven applicable for in vivo biomedical applications including fluorescence-guided disease diagnosis and theranostics (e.g., fluorogenic prodrugs). Impressive progresses have been made in the development of sensing agents and materials for the detection of ions, organic small molecules, and biomacromolecules including enzymes, DNAs/RNAs, lipids, and carbohydrates that play crucial roles in biological and disease-relevant events. Here, we highlight examples of fluorescent probes and functional materials for biological applications selected from the special issues “Fluorescent Probes” and “Molecular Sensors and Logic Gates” recently published in this journal, offering insights into the future development of powerful fluorescence-based chemical tools for basic biological studies and clinical translation.",

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note = "Funding Information: The authors thank the National Natural Science Foundation of China (Grant Nos. 21907030 and 22108077) and the International Cooperation Program of Shanghai Science and Technology Committee (Grant No. 19410712600). De-Tai Shi would like to thank the Natural Science Foundation of Jiangxi (Grant No. 20161BAB213067) and the Scientific Research Fund of Jiangxi Provincial Education Department (Grant No. GJJ170807). Tony D. James wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (Grant No. 2020ZD01). ",

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AU - Zou, Lei

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Fluorescent probes and functional materials for biomedical applications

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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