Fluorescent glycoprobes: a sweet addition for improved sensing

Xiao Peng He, Yi Zang, Tony D. James, Jia Li, Guo Rong Chen, Juan Xie

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The development of small-molecule fluorescent probes for the detection of ions and biomacromolecules and for cellular and in vivo imaging has been a very active research area. Nevertheless, many problems exist for traditional probes including their poor water solubility, toxicity and the inability to target specific tissues. Because of the enhanced water solubility, biocompatibility and targeting ability for specific cells, there has been an emerging movement to use carbohydrates as either the backbone or as a warhead to decorate conventional fluorescent probes, producing “glycoprobes” with enhanced properties. This feature article provides an overview of recently developed glycoprobes for ion and protein detection as well as targeted (receptor targeting) cellular imaging and theranostics. Here, we summarise the tactics for preparing small molecular glycoprobes and their supramolecular 2D material composites.

Original languageEnglish
Pages (from-to)82-90
Number of pages9
JournalChemical Communications
Volume53
Issue number1
Early online date4 Oct 2016
DOIs
Publication statusPublished - 4 Jan 2017

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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