Abstract
Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR.
| Original language | English |
|---|---|
| Pages (from-to) | 13235-13238 |
| Number of pages | 4 |
| Journal | Chemical communications (Cambridge, England) |
| Volume | 55 |
| Issue number | 88 |
| Early online date | 2 Oct 2019 |
| DOIs | |
| Publication status | Published - 14 Nov 2019 |
Keywords
- Biomarkers, Tumor/analysis
- Cell Line, Tumor
- Endothelial Protein C Receptor/analysis
- Female
- Fluorescent Dyes/chemistry
- Humans
- MCF-7 Cells
- Molecular Structure
- Optical Imaging
- Particle Size
- Peptides/chemistry
- Spectrometry, Fluorescence
- Surface Properties
- Triple Negative Breast Neoplasms/diagnostic imaging
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- General Chemistry
- Catalysis
