Fluorescence-detected magnetic field effects on radical pair reactions from femtolitre volumes

Charlotte Dodson; Christopher Wedge; Masai Murakami; Kiminori Maeda; Mark Wallace; Peter Hore

doi:10.1039/C5CC01099C

Fluorescence-detected magnetic field effects on radical pair reactions from femtolitre volumes

Charlotte Dodson, Christopher Wedge, Masai Murakami, Kiminori Maeda, Mark Wallace, Peter Hore

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

14 Citations (SciVal)

Abstract

We show that the effects of applied magnetic fields on radical pair reactions can be sensitively measured from sample volumes as low as ∼100 femtolitres using total internal reflection fluorescence microscopy. Development of a fluorescence-based microscope method is likely to be a key step in further miniaturisation that will allow detection of magnetic field effects on single molecules.

Original language	English
Pages (from-to)	8023-8026
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	51
Issue number	38
DOIs	https://doi.org/10.1039/C5CC01099C
Publication status	Published - 25 Mar 2015

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10.1039/C5CC01099C

Using single molecule spectroscopy to inform drug discovery in protein kinases
Dodson, C. (PI)
1/12/13 → 30/11/16
Project: Project at a former HEI

Charlotte Dodson, FHEA CChem
- C.A.Dodsonbath.acuk
- Department of Life Sciences - Senior Lecturer
- Centre for Therapeutic Innovation
Person: Research & Teaching

Cite this

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title = "Fluorescence-detected magnetic field effects on radical pair reactions from femtolitre volumes",

abstract = "We show that the effects of applied magnetic fields on radical pair reactions can be sensitively measured from sample volumes as low as ∼100 femtolitres using total internal reflection fluorescence microscopy. Development of a fluorescence-based microscope method is likely to be a key step in further miniaturisation that will allow detection of magnetic field effects on single molecules.",

author = "Charlotte Dodson and Christopher Wedge and Masai Murakami and Kiminori Maeda and Mark Wallace and Peter Hore",

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AU - Dodson, Charlotte

AU - Wedge, Christopher

AU - Murakami, Masai

AU - Maeda, Kiminori

AU - Wallace, Mark

AU - Hore, Peter

PY - 2015/3/25

Y1 - 2015/3/25

N2 - We show that the effects of applied magnetic fields on radical pair reactions can be sensitively measured from sample volumes as low as ∼100 femtolitres using total internal reflection fluorescence microscopy. Development of a fluorescence-based microscope method is likely to be a key step in further miniaturisation that will allow detection of magnetic field effects on single molecules.

AB - We show that the effects of applied magnetic fields on radical pair reactions can be sensitively measured from sample volumes as low as ∼100 femtolitres using total internal reflection fluorescence microscopy. Development of a fluorescence-based microscope method is likely to be a key step in further miniaturisation that will allow detection of magnetic field effects on single molecules.

U2 - 10.1039/C5CC01099C

DO - 10.1039/C5CC01099C

M3 - Article

SN - 1359-7345

VL - 51

SP - 8023

EP - 8026

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 38

ER -

Fluorescence-detected magnetic field effects on radical pair reactions from femtolitre volumes

Abstract

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Projects

Using single molecule spectroscopy to inform drug discovery in protein kinases

Profiles

Charlotte Dodson, FHEA CChem

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