Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

Ruggero Dondi; Elnaz Yaghini; Kunal Mahesh Tewari; Wang, Liguo; Francesca Giuntini; Marilena Loizidou; Sandy MacRobert; Ian Eggleston

doi:10.1039/C6OB02135B

Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

Ruggero Dondi, Elnaz Yaghini, Kunal Mahesh Tewari, Wang, Liguo, Francesca Giuntini, Marilena Loizidou, Sandy MacRobert, Ian Eggleston

Department of Life Sciences

University College London Hospitals NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

28 Citations (SciVal)

Abstract

Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).

Original language	English
Pages (from-to)	11488-11501
Number of pages	13
Journal	Organic and Biomolecular Chemistry
Volume	14
DOIs	https://doi.org/10.1039/C6OB02135B
Publication status	Published - 14 Nov 2016

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10.1039/C6OB02135BLicence: CC BY

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abstract = "Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).",

author = "Ruggero Dondi and Elnaz Yaghini and Tewari, {Kunal Mahesh} and Wang, Liguo and Francesca Giuntini and Marilena Loizidou and Sandy MacRobert and Ian Eggleston",

year = "2016",

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doi = "10.1039/C6OB02135B",

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journal = "Organic and Biomolecular Chemistry",

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publisher = "Royal Society of Chemistry",

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T1 - Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

AU - Dondi, Ruggero

AU - Yaghini, Elnaz

AU - Tewari, Kunal Mahesh

AU - Liguo, Wang,

AU - Giuntini, Francesca

AU - Loizidou, Marilena

AU - MacRobert, Sandy

AU - Eggleston, Ian

PY - 2016/11/14

Y1 - 2016/11/14

N2 - Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).

AB - Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).

UR - http://dx.doi.org/10.1039/C6OB02135B

U2 - 10.1039/C6OB02135B

DO - 10.1039/C6OB02135B

M3 - Article

SN - 1477-0520

VL - 14

SP - 11488

EP - 11501

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

ER -

Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

Abstract

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Peptide-Based Solutions for Light-Triggered Delivery of Macromolecular Therapeutics and Nanoparticles

IMPROVING THE DELIVERY OF 5-AMINOLAEVULINIC ACID IN PHOTODYN AMIC THERAPY

Avance III 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)

Avance NEO 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Electrospray Time-of-Flight Mass Spectrometer (Open-Access)

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Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

Abstract

Access to Document

Other files and links

Fingerprint

Projects

Peptide-Based Solutions for Light-Triggered Delivery of Macromolecular Therapeutics and Nanoparticles

IMPROVING THE DELIVERY OF 5-AMINOLAEVULINIC ACID IN PHOTODYN AMIC THERAPY

Equipment

Avance III 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)

Avance NEO 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Electrospray Time-of-Flight Mass Spectrometer (Open-Access)

Cite this