Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

Ruggero Dondi, Elnaz Yaghini, Kunal Mahesh Tewari, Wang, Liguo, Francesca Giuntini, Marilena Loizidou, Sandy MacRobert, Ian Eggleston

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).
Original languageEnglish
Pages (from-to)11488-11501
Number of pages13
JournalOrganic and Biomolecular Chemistry
Volume14
DOIs
Publication statusPublished - 14 Nov 2016

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