Projects per year
Abstract
Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).
Original language | English |
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Pages (from-to) | 11488-11501 |
Number of pages | 13 |
Journal | Organic and Biomolecular Chemistry |
Volume | 14 |
DOIs | |
Publication status | Published - 14 Nov 2016 |
Fingerprint
Dive into the research topics of 'Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy'. Together they form a unique fingerprint.Projects
- 2 Finished
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Peptide-Based Solutions for Light-Triggered Delivery of Macromolecular Therapeutics and Nanoparticles
Eggleston, I. (PI)
Biotechnology and Biological Sciences Research Council
16/07/12 → 15/07/15
Project: Research council
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IMPROVING THE DELIVERY OF 5-AMINOLAEVULINIC ACID IN PHOTODYN AMIC THERAPY
Eggleston, I. (PI)
Biotechnology and Biological Sciences Research Council
26/07/06 → 25/07/09
Project: Research council
Equipment
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Avance III 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)
Material and Chemical Characterisation (MC2)Facility/equipment: Equipment
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Electrospray Time-of-Flight Mass Spectrometer (Open-Access)
Material and Chemical Characterisation (MC2)Facility/equipment: Equipment