Flavin mimetics: Synthesis and photophysical properties

Dora M. Răsădean, Takashi Machida, Kazuki Sada, Christopher R. Pudney, G. Dan Pantoș

Research output: Contribution to journalArticlepeer-review

3 Citations (SciVal)


We report the synthesis of new isoalloxazines using a microwave-assisted approach to make N-substituted-2-nitroanilines followed by one-pot reduction and condensation via Hemmerich's method. The influence of substituents on positions 7, 8, and 10 of flavin core on the optical properties is investigated. The aliphatic functionalities on N10 give rise to quantum yields of 0.7, while aromatic side-chains quench fluorescence. Relaxed geometries (DFT) of chiral and achiral derivatives have been used for TD-DFT calculations, which yielded good agreement with the experimental UV and CD data.

Original languageEnglish
Article number131925
Early online date13 Jan 2021
Publication statusPublished - 26 Feb 2021

Bibliographical note

Funding Information:
This paper is a contribution to special issue in memory of Prof. Jon Williams. An excellent colleague and chemist, he was a strong presence in our department who is sorely missed. The authors gratefully acknowledge an EPSRC DTP (to D.M.R.) and the University of Bath for a visiting PhD researcher position (T.M.) which was also supported by Japan Student Services Organization (JASSO).


  • Chirality
  • Flavin
  • Fluorescence
  • Isoalloxazine
  • Microwave synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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