First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

Andrew M. Riley; Huanchen Wang; Jeremy D. Weaver; Stephen B. Shears; Barry V. L. Potter

doi:10.1039/c2cc36044f

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP₅ kinase

Andrew M. Riley, Huanchen Wang, Jeremy D. Weaver, Stephen B. Shears, Barry V. L. Potter

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

28 Citations (SciVal)

Abstract

We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP(5) mimics 5-PP-InsP(5) binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology of PP-InsPs.

Original language	English
Pages (from-to)	11292-11294
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	92
Early online date	17 Sept 2012
DOIs	https://doi.org/10.1039/c2cc36044f
Publication status	Published - 24 Oct 2012

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abstract = "We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP(5) mimics 5-PP-InsP(5) binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology of PP-InsPs.",

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AU - Riley, Andrew M.

AU - Wang, Huanchen

AU - Weaver, Jeremy D.

AU - Shears, Stephen B.

AU - Potter, Barry V. L.

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AB - We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP(5) mimics 5-PP-InsP(5) binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology of PP-InsPs.

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JO - Chemical Communications

JF - Chemical Communications

IS - 92

ER -

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP₅ kinase

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