First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

Andrew M. Riley, Huanchen Wang, Jeremy D. Weaver, Stephen B. Shears, Barry V. L. Potter

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP(5) mimics 5-PP-InsP(5) binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology of PP-InsPs.
Original languageEnglish
Pages (from-to)11292-11294
Number of pages3
JournalChemical Communications
Volume48
Issue number92
Early online date17 Sep 2012
DOIs
Publication statusPublished - 24 Oct 2012

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