Fine tuning T lymphocytes: A role for the lipid phosphatase SHIP-1

Richard V Parry, Stephanie J Harris, Stephen G Ward

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The phosphoinositide 3-kinase signaling pathway regulates a range of T lymphocyte cellular functions including growth, proliferation, cytokine secretion and survival. Aberrant regulation of phosphoinositide 3-kinase-dependent signaling in T lymphocytes has been implicated in inflammatory and autoimmune diseases. In common with much of the immune system, several mechanisms exist to ensure the pathway is tightly regulated to elicit appropriate responses. One level of control involves the Src homology 2 domain-containing inositol-5-phosphatase-1 (SHIP-1) that modulates phosphoinositide 3-kinase signaling by degrading the key signaling lipid PI(3,4,5)P3 to PI(3,4)P2, but also serves as a key scaffolding molecule in the formation of multi-protein complexes. Here we discuss the role of SHIP-1 in regulating T lymphocyte and immune function, as well as its potential as a therapeutic target.
Original languageEnglish
Pages (from-to)592-597
Number of pages6
JournalBiochimica et Biophysica Acta (BBA) - Proteins & Proteomics
Volume1804
Issue number3
DOIs
Publication statusPublished - 1 Mar 2010
Event6th International Conference on Inhibitors of Protein Kinases (IPK 2009) - Warsaw, Poland
Duration: 27 Jun 20091 Jul 2009

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