The phosphoinositide 3-kinase signaling pathway regulates a range of T lymphocyte cellular functions including growth, proliferation, cytokine secretion and survival. Aberrant regulation of phosphoinositide 3-kinase-dependent signaling in T lymphocytes has been implicated in inflammatory and autoimmune diseases. In common with much of the immune system, several mechanisms exist to ensure the pathway is tightly regulated to elicit appropriate responses. One level of control involves the Src homology 2 domain-containing inositol-5-phosphatase-1 (SHIP-1) that modulates phosphoinositide 3-kinase signaling by degrading the key signaling lipid PI(3,4,5)P3 to PI(3,4)P2, but also serves as a key scaffolding molecule in the formation of multi-protein complexes. Here we discuss the role of SHIP-1 in regulating T lymphocyte and immune function, as well as its potential as a therapeutic target.
|Number of pages||6|
|Journal||Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics|
|Publication status||Published - 1 Mar 2010|
|Event||6th International Conference on Inhibitors of Protein Kinases (IPK 2009) - Warsaw, Poland|
Duration: 27 Jun 2009 → 1 Jul 2009
Parry, R. V., Harris, S. J., & Ward, S. G. (2010). Fine tuning T lymphocytes: A role for the lipid phosphatase SHIP-1. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1804(3), 592-597. https://doi.org/10.1016/j.bbapap.2009.09.019