Fiber four-wave mixing source for coherent anti-Stokes Raman scattering microscopy

Simon Lefrancois, Dan Fu, Gary R. Holtom, Lingjie Kong, William J. Wadsworth, Patrick Schneider, Robert Herda, Armin Zach, X. Sunney Xie, Frank W. Wise

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Abstract

We present a fiber-format picosecond light source for coherent anti-Stokes Raman scattering microscopy. Pulses from a Yb-doped fiber amplifier are frequency converted by four-wave mixing (FWM) in normal-dispersion photonic crystal fiber to produce a synchronized two-color picosecond pulse train. We show that seeding the FWM process overcomes the deleterious effects of group-velocity mismatch and allows efficient conversion into narrow frequency bands. The source generates more than 160 mW of nearly transform-limited pulses tunable from 775 to 815 nm. High-quality coherent Raman images of animal tissues and cells acquired with this source are presented.
Original languageEnglish
Pages (from-to)1652-1654
JournalOptics Letters
Volume37
Issue number10
DOIs
Publication statusPublished - 15 May 2012

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    Lefrancois, S., Fu, D., Holtom, G. R., Kong, L., Wadsworth, W. J., Schneider, P., Herda, R., Zach, A., Sunney Xie, X., & Wise, F. W. (2012). Fiber four-wave mixing source for coherent anti-Stokes Raman scattering microscopy. Optics Letters, 37(10), 1652-1654. https://doi.org/10.1364/OL.37.001652