Fiber four-wave mixing source for coherent anti-Stokes Raman scattering microscopy

Simon Lefrancois; Dan Fu; Gary R. Holtom; Lingjie Kong; William J. Wadsworth; Patrick Schneider; Robert Herda; Armin Zach; X. Sunney Xie; Frank W. Wise

doi:10.1364/OL.37.001652

Fiber four-wave mixing source for coherent anti-Stokes Raman scattering microscopy

Simon Lefrancois, Dan Fu, Gary R. Holtom, Lingjie Kong, William J. Wadsworth, Patrick Schneider, Robert Herda, Armin Zach, X. Sunney Xie, Frank W. Wise

Department of Physics

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Abstract

We present a fiber-format picosecond light source for coherent anti-Stokes Raman scattering microscopy. Pulses from a Yb-doped fiber amplifier are frequency converted by four-wave mixing (FWM) in normal-dispersion photonic crystal fiber to produce a synchronized two-color picosecond pulse train. We show that seeding the FWM process overcomes the deleterious effects of group-velocity mismatch and allows efficient conversion into narrow frequency bands. The source generates more than 160 mW of nearly transform-limited pulses tunable from 775 to 815 nm. High-quality coherent Raman images of animal tissues and cells acquired with this source are presented.

Original language	English
Pages (from-to)	1652-1654
Journal	Optics Letters
Volume	37
Issue number	10
DOIs	https://doi.org/10.1364/OL.37.001652
Publication status	Published - 15 May 2012

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10.1364/OL.37.001652

Wadsworth Opt Lett 37 10 1652
© 2012 OSA. This paper was published in Optics Letters and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OL.37.001652. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.
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title = "Fiber four-wave mixing source for coherent anti-Stokes Raman scattering microscopy",

abstract = "We present a fiber-format picosecond light source for coherent anti-Stokes Raman scattering microscopy. Pulses from a Yb-doped fiber amplifier are frequency converted by four-wave mixing (FWM) in normal-dispersion photonic crystal fiber to produce a synchronized two-color picosecond pulse train. We show that seeding the FWM process overcomes the deleterious effects of group-velocity mismatch and allows efficient conversion into narrow frequency bands. The source generates more than 160 mW of nearly transform-limited pulses tunable from 775 to 815 nm. High-quality coherent Raman images of animal tissues and cells acquired with this source are presented.",

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AU - Lefrancois, Simon

AU - Fu, Dan

AU - Holtom, Gary R.

AU - Kong, Lingjie

AU - Wadsworth, William J.

AU - Schneider, Patrick

AU - Herda, Robert

AU - Zach, Armin

AU - Sunney Xie, X.

AU - Wise, Frank W.

PY - 2012/5/15

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AB - We present a fiber-format picosecond light source for coherent anti-Stokes Raman scattering microscopy. Pulses from a Yb-doped fiber amplifier are frequency converted by four-wave mixing (FWM) in normal-dispersion photonic crystal fiber to produce a synchronized two-color picosecond pulse train. We show that seeding the FWM process overcomes the deleterious effects of group-velocity mismatch and allows efficient conversion into narrow frequency bands. The source generates more than 160 mW of nearly transform-limited pulses tunable from 775 to 815 nm. High-quality coherent Raman images of animal tissues and cells acquired with this source are presented.

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Fiber four-wave mixing source for coherent anti-Stokes Raman scattering microscopy

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