[Fe(Htrz)2(trz)](BF4) nanoparticle production in a milli-scale segmented flow crystalliser

Karen Robertson, Pierre-Baptiste Flandrin, Helena J Shepherd, Charles Wilson

Research output: Contribution to journalArticlepeer-review

7 Citations (SciVal)


Microfluidics has become well established as the benchmark method of nanoparticle production but the need for special equipment and the challenge of scale-up can make it prohibitive for many laboratories. In contrast, the larger scale millifluidics methodology provides a platform for controlled nanoparticle production in a simple set-up without risk of blockages, increasing the volume of material produced while continuing to offer control over particle attributes. Nanoparticle size can have a profound effect on the properties exhibited, in the case of spin-crossover materials the size of nanoparticles can have a direct correspondence with the hysteresis of magnetic susceptibility vs temperature. Nanoparticle synthesis of the spin-crossover coordination polymer [Fe(Htrz)2(trz)](BF4) (Htrz = 1,2,4-1H-triazole) has hitherto been reported through batch methods alone. Here we present the first flow synthesis of [Fe(Htrz)2(trz)](BF4) in a milli-scale segmented flow crystalliser (the Kinetically
Regulated Automated Input Crystalliser, KRAIC).
Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalChimica Oggi-Chemistry Today
Issue number1
Publication statusPublished - 1 Jan 2017


  • Nanoparticles
  • flow crystallisation
  • Mesofluidics
  • milli
  • spin-crossover
  • flow chemistry


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