Fast and accurate diffusion NMR acquisition in continuous flow

Isabel A Thomlinson; Matthew G Davidson; Catherine L Lyall; John P Lowe; Ulrich Hintermair

doi:10.1039/d2cc03054c

Fast and accurate diffusion NMR acquisition in continuous flow

Isabel A Thomlinson, Matthew G Davidson, Catherine L Lyall, John P Lowe, Ulrich Hintermair

Dynamic Reaction Monitoring Facility

Research output: Contribution to journal › Article › peer-review

7 Citations (SciVal)

Abstract

FlowNMR spectroscopy has become a popular and powerful technique for online reaction monitoring. DOSY NMR is an established technique for obtaining information about diffusion rates and molecular size on static samples. This work extends the FlowNMR toolbox to include FlowDOSY based on convection compensation and use of a low-pulsation pump or flow effect correction, allowing accurate and precise diffusion coefficients to be obtained at flow rates up to 4.0 mL min-1 in less than 5 minutes.

Original language	English
Pages (from-to)	8242-8245
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	58
Issue number	59
Early online date	4 Jul 2022
DOIs	https://doi.org/10.1039/d2cc03054c
Publication status	Published - 21 Jul 2022

Bibliographical note

This work was supported by the Royal Society (Fellowship UF160458 to UH), the EPSRC (Dynamic Reaction Monitoring Facility EP/P001475/1 and Centre for Doctoral Training in Sustainable Chemical Technologies EP/L016354/1) and the University of Bath. We thank Peter Gierth (Bruker UK) for support and assistance with this project.

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d2cc03054cLicence: CC BY

Cite this

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abstract = "FlowNMR spectroscopy has become a popular and powerful technique for online reaction monitoring. DOSY NMR is an established technique for obtaining information about diffusion rates and molecular size on static samples. This work extends the FlowNMR toolbox to include FlowDOSY based on convection compensation and use of a low-pulsation pump or flow effect correction, allowing accurate and precise diffusion coefficients to be obtained at flow rates up to 4.0 mL min-1 in less than 5 minutes.",

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note = "This work was supported by the Royal Society (Fellowship UF160458 to UH), the EPSRC (Dynamic Reaction Monitoring Facility EP/P001475/1 and Centre for Doctoral Training in Sustainable Chemical Technologies EP/L016354/1) and the University of Bath. We thank Peter Gierth (Bruker UK) for support and assistance with this project.",

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T1 - Fast and accurate diffusion NMR acquisition in continuous flow

AU - Thomlinson, Isabel A

AU - Davidson, Matthew G

AU - Lyall, Catherine L

AU - Lowe, John P

AU - Hintermair, Ulrich

N1 - This work was supported by the Royal Society (Fellowship UF160458 to UH), the EPSRC (Dynamic Reaction Monitoring Facility EP/P001475/1 and Centre for Doctoral Training in Sustainable Chemical Technologies EP/L016354/1) and the University of Bath. We thank Peter Gierth (Bruker UK) for support and assistance with this project.

PY - 2022/7/21

Y1 - 2022/7/21

N2 - FlowNMR spectroscopy has become a popular and powerful technique for online reaction monitoring. DOSY NMR is an established technique for obtaining information about diffusion rates and molecular size on static samples. This work extends the FlowNMR toolbox to include FlowDOSY based on convection compensation and use of a low-pulsation pump or flow effect correction, allowing accurate and precise diffusion coefficients to be obtained at flow rates up to 4.0 mL min-1 in less than 5 minutes.

AB - FlowNMR spectroscopy has become a popular and powerful technique for online reaction monitoring. DOSY NMR is an established technique for obtaining information about diffusion rates and molecular size on static samples. This work extends the FlowNMR toolbox to include FlowDOSY based on convection compensation and use of a low-pulsation pump or flow effect correction, allowing accurate and precise diffusion coefficients to be obtained at flow rates up to 4.0 mL min-1 in less than 5 minutes.

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U2 - 10.1039/d2cc03054c

DO - 10.1039/d2cc03054c

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VL - 58

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EP - 8245

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 59

ER -

Fast and accurate diffusion NMR acquisition in continuous flow

Abstract

Bibliographical note

ASJC Scopus subject areas

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An Integrated, Multi-Dimensional In-Operando Reaction Monitoring Facility for Homogenous Catalysis Research

Cite this

Fast and accurate diffusion NMR acquisition in continuous flow

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

An Integrated, Multi-Dimensional In-Operando Reaction Monitoring Facility for Homogenous Catalysis Research

Cite this