Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects

Andong Shao; Yongshu Xie; Shaojia Zhu; Zhiqian Guo; Shiqin Zhu; Jin Guo; Ping Shi; Tony D. James; He Tian; Wei Hong Zhu

doi:10.1002/anie.201501478

Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects

Andong Shao
, Yongshu Xie
, Shaojia Zhu
, Zhiqian Guo
, Shiqin Zhu
, Jin Guo
, Ping Shi
, Tony D. James
, He Tian
, Wei Hong Zhu

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

400 Citations (SciVal)

924 Downloads (Pure)

Abstract

The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.

Original language	English
Pages (from-to)	7275-7280
Number of pages	6
Journal	Angewandte Chemie International Edition
Volume	54
Issue number	25
Early online date	7 May 2015
DOIs	https://doi.org/10.1002/anie.201501478
Publication status	Published - 15 Jun 2015

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SDG 3 Good Health and Well-being

Keywords

Aggregation-induced emission
Fluorescent probes
Morphology effects
Near infrared
Tumor targeting

Access to Document

10.1002/anie.201501478

anie.201501478R1_Double line format.pdf
This is the accepted version of the following article: Shao, A, Xie, Y, Zhu, S, Guo, Z, Zhu, S, Guo, J, Shi, P, James, TD, Tian, H & Zhu, WH 2015, 'Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects' Angewandte Chemie-International Edition, vol 54, no. 25, pp. 7275-7280., which has been published in final form at https://doi.org/10.1002/anie.201501478
Accepted author manuscript, 1.51 MB

Tony James
- T.D.Jamesbath.acuk
Person: Research & Teaching, Affiliate staff

Cite this

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title = "Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects",

abstract = "The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.",

keywords = "Aggregation-induced emission, Fluorescent probes, Morphology effects, Near infrared, Tumor targeting",

author = "Andong Shao and Yongshu Xie and Shaojia Zhu and Zhiqian Guo and Shiqin Zhu and Jin Guo and Ping Shi and James, \{Tony D.\} and He Tian and Zhu, \{Wei Hong\}",

year = "2015",

month = jun,

day = "15",

doi = "10.1002/anie.201501478",

language = "English",

volume = "54",

pages = "7275--7280",

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TY - JOUR

T1 - Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy

T2 - Shape-Specific Effects

AU - Shao, Andong

AU - Xie, Yongshu

AU - Zhu, Shaojia

AU - Guo, Zhiqian

AU - Zhu, Shiqin

AU - Guo, Jin

AU - Shi, Ping

AU - James, Tony D.

AU - Tian, He

AU - Zhu, Wei Hong

PY - 2015/6/15

Y1 - 2015/6/15

N2 - The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.

AB - The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.

KW - Aggregation-induced emission

KW - Fluorescent probes

KW - Morphology effects

KW - Near infrared

KW - Tumor targeting

U2 - 10.1002/anie.201501478

DO - 10.1002/anie.201501478

M3 - Article

SN - 1433-7851

VL - 54

SP - 7275

EP - 7280

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 25

ER -

Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects

Abstract

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Keywords

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