Abstract
The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.
Original language | English |
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Pages (from-to) | 7275-7280 |
Number of pages | 6 |
Journal | Angewandte Chemie-International Edition |
Volume | 54 |
Issue number | 25 |
Early online date | 7 May 2015 |
DOIs | |
Publication status | Published - 15 Jun 2015 |
Keywords
- Aggregation-induced emission
- Fluorescent probes
- Morphology effects
- Near infrared
- Tumor targeting