Abstract
The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.
| Original language | English |
|---|---|
| Pages (from-to) | 7275-7280 |
| Number of pages | 6 |
| Journal | Angewandte Chemie-International Edition |
| Volume | 54 |
| Issue number | 25 |
| Early online date | 7 May 2015 |
| DOIs | |
| Publication status | Published - 15 Jun 2015 |
Keywords
- Aggregation-induced emission
- Fluorescent probes
- Morphology effects
- Near infrared
- Tumor targeting
Access to Document
- anie.201501478R1_Double line format.pdf
This is the accepted version of the following article: Shao, A, Xie, Y, Zhu, S, Guo, Z, Zhu, S, Guo, J, Shi, P, James, TD, Tian, H & Zhu, WH 2015, 'Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects' Angewandte Chemie-International Edition, vol 54, no. 25, pp. 7275-7280., which has been published in final form at https://doi.org/10.1002/anie.201501478
