Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects

Andong Shao; Yongshu Xie; Shaojia Zhu; Zhiqian Guo; Shiqin Zhu; Jin Guo; Ping Shi; Tony D. James; He Tian; Wei Hong Zhu

doi:10.1002/anie.201501478

Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects

Andong Shao, Yongshu Xie, Shaojia Zhu, Zhiqian Guo, Shiqin Zhu, Jin Guo, Ping Shi, Tony D. James, He Tian, Wei Hong Zhu

East China University of Science and Technology

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Abstract

The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.

Original language	English
Pages (from-to)	7275-7280
Number of pages	6
Journal	Angewandte Chemie International Edition
Volume	54
Issue number	25
Early online date	7 May 2015
DOIs	https://doi.org/10.1002/anie.201501478
Publication status	Published - 15 Jun 2015

Keywords

Aggregation-induced emission
Fluorescent probes
Morphology effects
Near infrared
Tumor targeting

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201501478

anie.201501478R1_Double line format.pdf
This is the accepted version of the following article: Shao, A, Xie, Y, Zhu, S, Guo, Z, Zhu, S, Guo, J, Shi, P, James, TD, Tian, H & Zhu, WH 2015, 'Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects' Angewandte Chemie-International Edition, vol 54, no. 25, pp. 7275-7280., which has been published in final form at https://doi.org/10.1002/anie.201501478
Accepted author manuscript, 1.51 MB

Tony James
- T.D.Jamesbath.acuk
Person: Research & Teaching, Affiliate staff

Cite this

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title = "Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects",

abstract = "The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.",

keywords = "Aggregation-induced emission, Fluorescent probes, Morphology effects, Near infrared, Tumor targeting",

author = "Andong Shao and Yongshu Xie and Shaojia Zhu and Zhiqian Guo and Shiqin Zhu and Jin Guo and Ping Shi and James, {Tony D.} and He Tian and Zhu, {Wei Hong}",

year = "2015",

month = jun,

day = "15",

doi = "10.1002/anie.201501478",

language = "English",

volume = "54",

pages = "7275--7280",

journal = "Angewandte Chemie International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy

T2 - Shape-Specific Effects

AU - Shao, Andong

AU - Xie, Yongshu

AU - Zhu, Shaojia

AU - Guo, Zhiqian

AU - Zhu, Shiqin

AU - Guo, Jin

AU - Shi, Ping

AU - James, Tony D.

AU - Tian, He

AU - Zhu, Wei Hong

PY - 2015/6/15

Y1 - 2015/6/15

N2 - The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.

AB - The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.

KW - Aggregation-induced emission

KW - Fluorescent probes

KW - Morphology effects

KW - Near infrared

KW - Tumor targeting

U2 - 10.1002/anie.201501478

DO - 10.1002/anie.201501478

M3 - Article

SN - 1433-7851

VL - 54

SP - 7275

EP - 7280

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 25

ER -

Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects

Abstract

Keywords

UN SDGs

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