Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects

Andong Shao, Yongshu Xie, Shaojia Zhu, Zhiqian Guo, Shiqin Zhu, Jin Guo, Ping Shi, Tony D. James, He Tian, Wei Hong Zhu

Research output: Contribution to journalArticlepeer-review

271 Citations (Scopus)
283 Downloads (Pure)

Abstract

The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.

Original languageEnglish
Pages (from-to)7275-7280
Number of pages6
JournalAngewandte Chemie-International Edition
Volume54
Issue number25
Early online date7 May 2015
DOIs
Publication statusPublished - 15 Jun 2015

Keywords

  • Aggregation-induced emission
  • Fluorescent probes
  • Morphology effects
  • Near infrared
  • Tumor targeting

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