Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.
Fan, X., Sans, V., Yaseneva, P., Plaza, D. D., Williams, J., & Lapkin, A. (2012). Facile stoichiometric reductions in flow: An example of artemisinin. Organic Process Research and Development, 16(5), 1039-1042. https://doi.org/10.1021/op200373m