Facile stoichiometric reductions in flow: An example of artemisinin

X. Fan, V. Sans, P. Yaseneva, D. D. Plaza, Jonathan Williams, A. Lapkin

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.
Original languageEnglish
Pages (from-to)1039-1042
Number of pages4
JournalOrganic Process Research and Development
Volume16
Issue number5
DOIs
Publication statusPublished - 2012

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    Fan, X., Sans, V., Yaseneva, P., Plaza, D. D., Williams, J., & Lapkin, A. (2012). Facile stoichiometric reductions in flow: An example of artemisinin. Organic Process Research and Development, 16(5), 1039-1042. https://doi.org/10.1021/op200373m