Facile stoichiometric reductions in flow: An example of artemisinin

X. Fan, V. Sans, P. Yaseneva, D. D. Plaza, Jonathan Williams, A. Lapkin

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.
Original languageEnglish
Pages (from-to)1039-1042
Number of pages4
JournalOrganic Process Research and Development
Volume16
Issue number5
DOIs
Publication statusPublished - 2012

Fingerprint

dihydroartemisinin
productivity
selectivity
Productivity
Throughput
artemisinine

Cite this

Fan, X., Sans, V., Yaseneva, P., Plaza, D. D., Williams, J., & Lapkin, A. (2012). Facile stoichiometric reductions in flow: An example of artemisinin. Organic Process Research and Development, 16(5), 1039-1042. https://doi.org/10.1021/op200373m

Facile stoichiometric reductions in flow: An example of artemisinin. / Fan, X.; Sans, V.; Yaseneva, P.; Plaza, D. D.; Williams, Jonathan; Lapkin, A.

In: Organic Process Research and Development, Vol. 16, No. 5, 2012, p. 1039-1042.

Research output: Contribution to journalArticle

Fan, X, Sans, V, Yaseneva, P, Plaza, DD, Williams, J & Lapkin, A 2012, 'Facile stoichiometric reductions in flow: An example of artemisinin', Organic Process Research and Development, vol. 16, no. 5, pp. 1039-1042. https://doi.org/10.1021/op200373m
Fan, X. ; Sans, V. ; Yaseneva, P. ; Plaza, D. D. ; Williams, Jonathan ; Lapkin, A. / Facile stoichiometric reductions in flow: An example of artemisinin. In: Organic Process Research and Development. 2012 ; Vol. 16, No. 5. pp. 1039-1042.
@article{1f911439c8794a4c97c7012e1279b9ea,
title = "Facile stoichiometric reductions in flow: An example of artemisinin",
abstract = "Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.",
author = "X. Fan and V. Sans and P. Yaseneva and Plaza, {D. D.} and Jonathan Williams and A. Lapkin",
year = "2012",
doi = "10.1021/op200373m",
language = "English",
volume = "16",
pages = "1039--1042",
journal = "Organic Process Research and Development",
issn = "1083-6160",
publisher = "American Chemical Society",
number = "5",

}

TY - JOUR

T1 - Facile stoichiometric reductions in flow: An example of artemisinin

AU - Fan, X.

AU - Sans, V.

AU - Yaseneva, P.

AU - Plaza, D. D.

AU - Williams, Jonathan

AU - Lapkin, A.

PY - 2012

Y1 - 2012

N2 - Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.

AB - Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.

UR - http://www.scopus.com/inward/record.url?scp=84862101865&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1021/op200373m

U2 - 10.1021/op200373m

DO - 10.1021/op200373m

M3 - Article

VL - 16

SP - 1039

EP - 1042

JO - Organic Process Research and Development

JF - Organic Process Research and Development

SN - 1083-6160

IS - 5

ER -