Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces via an epoxide plasma polymer interlayer

Thomas D. Michl, Carla Giles, Alasdair T. Cross, Hans J. Griesser, Bryan R. Coad

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We report a facile, one-step, aqueous surface bioconjugation approach for producing an antifungal surface coating that prevents the formation of fungal biofilms. By direct reaction between surface epoxide groups and amine groups on caspofungin, it avoids the use of secondary chemicals. The coating withstands washing with detergent and reduces the growth of the fungal pathogens Candida albicans by log 6 and Candida glabrata by log 3. Importantly, we show that surface adsorption of albumin does not inhibit the activity of this antifungal coating.

Original languageEnglish
Pages (from-to)27678-27681
Number of pages4
JournalRSC Advances
Volume7
Issue number44
DOIs
Publication statusPublished - 24 May 2017

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Fingerprint Dive into the research topics of 'Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces <i>via </i>an epoxide plasma polymer interlayer'. Together they form a unique fingerprint.

  • Cite this